Sandbox Reserved 1120

The SRY protein is a monomeric 203 residues long polypeptide. It is a transcriptionnal factor, more precisely a transcriptionnal activator of the Müllerian Inhibiting Substance (MIS gene). It is encoded by the testis-determining sex gene and is itself involved in the sex determination in mammels by being responsible for the male sexual developement.

History

It has been shown that a mutation of SRY increase male to female sex reversal for 15% REF NECESSAIRE

SRY gene

The SRY gene encodes the SRY protein. It is located on the Y chromosom.

Structure

The SRY-HMG domain

SRY-HMG stands for Sex determining Region Y - High Mobility Domain It is a approximately 80 residues domain. It mediates minor groove DNA binding proteins. Twisted L shape : Concave surface. 3 helices & N and C end strands. Binds the DNA by its minor groove. 2 kinds of HMG domain:

• HMG1
• HMG2

General structure of SRY

3 domains:

• N-term domain
• Central domain
• C-term domain

Function

Sex determining

It acts like a sex determinator thanks to it transcriptionnal activity. It inhibits the developpement of female sex structure in th embryonnic individual.

Implication - Future for SRY ?

Disease

Relevance

Structural highlights

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