The SRY protein is a monomeric 203 residues long polypeptide. It is a transcriptionnal factor, more precisely a transcriptionnal activator of the Müllerian Inhibiting Substance (MIS gene).
It is encoded by the testis-determining sex gene and is itself involved in the sex determination in mammels by being responsible for the male sexual developement.
History
It has been shown that a mutation of SRY increase male to female sex reversal for 15% REF NECESSAIRE
SRY gene
The SRY gene encodes the SRY protein. It is located on the Y chromosom.
Structure
The SRY-HMG domain
SRY-HMG stands for Sex determining Region Y - High Mobility Domain
It is a approximately 80 residues domain. It mediates minor groove DNA binding proteins.
Twisted L shape : Concave surface. 3 helices & N and C end strands.
Binds the DNA by its minor groove.
2 kinds of HMG domain:
General structure of SRY
3 domains:
- N-term domain
- Central domain
- C-term domain
Structure of the DNA target site
Function
Sex determining
It acts like a sex determinator thanks to it transcriptionnal activity. It inhibits the developpement of female sex structure in th embryonnic individual.
Implication - Future for SRY ?
Disease
Relevance
Structural highlights
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