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Calpain

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Line 36: Line 36:
**[[1nx1]] - pCAP domain VI + Ca+ Calpastatin peptide<br />
**[[1nx1]] - pCAP domain VI + Ca+ Calpastatin peptide<br />
**[[4phj]] – hCAP EF-hand subunit + Ca - human<br />
**[[4phj]] – hCAP EF-hand subunit + Ca - human<br />
-
**[[4phk]], [[4phm]], [[4phn]] – hCAP EF-hand subunit + Ca + inhibitor<br />
+
**[[4phk]], [[4phm]], [[4phn]], [[4wq2]], [[4wq3]], [[5d69]] – hCAP EF-hand subunit + Ca + inhibitor<br />
*CAP1
*CAP1

Revision as of 08:43, 23 March 2017

Human calpain1 large subunit complex with inhibitor and Ca+2 ions (green) (PDB entry 1zcm)

Drag the structure with the mouse to rotate

3D structures of calpain

Updated on 23-March-2017

References

  1. ↑ Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev. 2003 Jul;83(3):731-801. PMID:12843408 doi:http://dx.doi.org/10.1152/physrev.00029.2002
  2. ↑ Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL. A Ca(2+) switch aligns the active site of calpain. Cell. 2002 Mar 8;108(5):649-60. PMID:11893336
  3. ↑ Li Q, Hanzlik RP, Weaver RF, Schonbrunn E. Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core. Biochemistry. 2006 Jan 24;45(3):701-8. PMID:16411745 doi:http://dx.doi.org/10.1021/bi052077b

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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