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In 1992, PD-1 cDNA was discovered by Ishida et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/1396582</ref>.
In 1992, PD-1 cDNA was discovered by Ishida et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/1396582</ref>.
Thanks to the studies on PD-1-deficient mice on the C57BL/6 background, PD-1 begun to be understood, even if its precise function still unknown at this time.
Thanks to the studies on PD-1-deficient mice on the C57BL/6 background, PD-1 begun to be understood, even if its precise function still unknown at this time.
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Still, the role of PD-1 in deficiency and autoimmunity was suggested<ref>http://intimm.oxfordjournals.org/content/19/7/813.full.pdf</ref>.
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Still, the role of PD-1 in deficiency and autoimmunity was suggested<ref>doi:10.1093/intimm/dxm057</ref>.
<br/>In 1994, Shinohara et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/7851902</ref>. (1994) succeeded in characterizing the human homolog of the mouse gene and the similarity was of 60% for amino acids, with a well-conserved tyrosine-kinase association motif.
<br/>In 1994, Shinohara et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/7851902</ref>. (1994) succeeded in characterizing the human homolog of the mouse gene and the similarity was of 60% for amino acids, with a well-conserved tyrosine-kinase association motif.
<br/>In 1997, Finger et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/9332365</ref>. (1997) achieved the complete sequencing of the cDNA of the PD-1 gene.
<br/>In 1997, Finger et al<ref>http://www.ncbi.nlm.nih.gov/pubmed/9332365</ref>. (1997) achieved the complete sequencing of the cDNA of the PD-1 gene.

Revision as of 18:31, 30 January 2016

PD-1 structure (PDB entry 2m2d)

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