2x4s

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==CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PEPTIDE REPRESENTING THE EPITOPE OF THE H5N1 (AVIAN FLU) NUCLEOPROTEIN==
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==Crystal structure of MHC CLass I HLA-A2.1 bound to a peptide representing the epitope of the H5N1 (Avian Flu) Nucleoprotein==
<StructureSection load='2x4s' size='340' side='right' caption='[[2x4s]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='2x4s' size='340' side='right' caption='[[2x4s]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uqs|1uqs]], [[1bd2|1bd2]], [[2esv|2esv]], [[2ak4|2ak4]], [[1ypz|1ypz]], [[1im3|1im3]], [[1uxw|1uxw]], [[1i7u|1i7u]], [[1c16|1c16]], [[1hsa|1hsa]], [[1gzp|1gzp]], [[2axf|2axf]], [[2bnq|2bnq]], [[1w72|1w72]], [[2jcc|2jcc]], [[2bck|2bck]], [[1de4|1de4]], [[2vlk|2vlk]], [[1exu|1exu]], [[1qrn|1qrn]], [[2hla|2hla]], [[1mhe|1mhe]], [[1im9|1im9]], [[1eez|1eez]], [[1jht|1jht]], [[1qqd|1qqd]], [[1qr1|1qr1]], [[1zs8|1zs8]], [[1hla|1hla]], [[1jgd|1jgd]], [[1i1y|1i1y]], [[1vgk|1vgk]], [[1age|1age]], [[1ur7|1ur7]], [[1hhg|1hhg]], [[1s9x|1s9x]], [[1a9e|1a9e]], [[1duz|1duz]], [[2clr|2clr]], [[3hla|3hla]], [[1m05|1m05]], [[1tvb|1tvb]], [[2v2w|2v2w]], [[1onq|1onq]], [[2vlr|2vlr]], [[1a1n|1a1n]], [[2bvo|2bvo]], [[1lp9|1lp9]], [[1zsd|1zsd]], [[1m6o|1m6o]], [[1hhk|1hhk]], [[1hsb|1hsb]], [[1zt4|1zt4]], [[1x7q|1x7q]], [[1ce6|1ce6]], [[1py4|1py4]], [[1syv|1syv]], [[2j8u|2j8u]], [[1sys|1sys]], [[1ogt|1ogt]], [[1cg9|1cg9]], [[1p7q|1p7q]], [[1q94|1q94]], [[1jnj|1jnj]], [[1agb|1agb]], [[2d31|2d31]], [[1aqd|1aqd]], [[1xz0|1xz0]], [[1lds|1lds]], [[1tvh|1tvh]], [[1hhh|1hhh]], [[1xr8|1xr8]], [[2bss|2bss]], [[1e28|1e28]], [[1a1m|1a1m]], [[2bvp|2bvp]], [[2v2x|2v2x]], [[1xr9|1xr9]], [[2gj6|2gj6]], [[1qlf|1qlf]], [[1efx|1efx]], [[2av1|2av1]], [[1tmc|1tmc]], [[1qsf|1qsf]], [[1duy|1duy]], [[1kpr|1kpr]], [[1jge|1jge]], [[2hjl|2hjl]], [[1qew|1qew]], [[1w0v|1w0v]], [[1k5n|1k5n]], [[1ao7|1ao7]], [[2bnr|2bnr]], [[1xh3|1xh3]], [[2bst|2bst]], [[1mi5|1mi5]], [[2h26|2h26]], [[1s9y|1s9y]], [[1a1o|1a1o]], [[2a83|2a83]], [[1agf|1agf]], [[1oga|1oga]], [[2f8o|2f8o]], [[2cii|2cii]], [[1i7r|1i7r]], [[1jf1|1jf1]], [[2c7u|2c7u]], [[1e27|1e27]], [[2f74|2f74]], [[1w0w|1w0w]], [[1gzq|1gzq]], [[1uxs|1uxs]], [[1akj|1akj]], [[2hjk|2hjk]], [[2vb5|2vb5]], [[1agd|1agd]], [[1r3h|1r3h]], [[1eey|1eey]], [[1i7t|1i7t]], [[1i4f|1i4f]], [[1ydp|1ydp]], [[2vll|2vll]], [[2bsr|2bsr]], [[2vlj|2vlj]], [[1b0r|1b0r]], [[1b0g|1b0g]], [[1of2|1of2]], [[1hhi|1hhi]], [[1qse|1qse]], [[2axg|2axg]], [[1a9b|1a9b]], [[2bvq|2bvq]], [[1agc|1agc]], [[1hhj|1hhj]], [[1qvo|1qvo]], [[1s9w|1s9w]], [[1ktl|1ktl]], [[1a6z|1a6z]], [[2cik|2cik]], [[2uwe|2uwe]], [[1i1f|1i1f]], [[2av7|2av7]], [[2x4r|2x4r]], [[2x4o|2x4o]], [[2x4u|2x4u]], [[2x4p|2x4p]], [[2x4q|2x4q]], [[2x4t|2x4t]], [[2x4n|2x4n]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uqs|1uqs]], [[1bd2|1bd2]], [[2esv|2esv]], [[2ak4|2ak4]], [[1ypz|1ypz]], [[1im3|1im3]], [[1uxw|1uxw]], [[1i7u|1i7u]], [[1c16|1c16]], [[1hsa|1hsa]], [[1gzp|1gzp]], [[2axf|2axf]], [[2bnq|2bnq]], [[1w72|1w72]], [[2jcc|2jcc]], [[2bck|2bck]], [[1de4|1de4]], [[2vlk|2vlk]], [[1exu|1exu]], [[1qrn|1qrn]], [[2hla|2hla]], [[1mhe|1mhe]], [[1im9|1im9]], [[1eez|1eez]], [[1jht|1jht]], [[1qqd|1qqd]], [[1qr1|1qr1]], [[1zs8|1zs8]], [[1hla|1hla]], [[1jgd|1jgd]], [[1i1y|1i1y]], [[1vgk|1vgk]], [[1age|1age]], [[1ur7|1ur7]], [[1hhg|1hhg]], [[1s9x|1s9x]], [[1a9e|1a9e]], [[1duz|1duz]], [[2clr|2clr]], [[3hla|3hla]], [[1m05|1m05]], [[1tvb|1tvb]], [[2v2w|2v2w]], [[1onq|1onq]], [[2vlr|2vlr]], [[1a1n|1a1n]], [[2bvo|2bvo]], [[1lp9|1lp9]], [[1zsd|1zsd]], [[1m6o|1m6o]], [[1hhk|1hhk]], [[1hsb|1hsb]], [[1zt4|1zt4]], [[1x7q|1x7q]], [[1ce6|1ce6]], [[1py4|1py4]], [[1syv|1syv]], [[2j8u|2j8u]], [[1sys|1sys]], [[1ogt|1ogt]], [[1cg9|1cg9]], [[1p7q|1p7q]], [[1q94|1q94]], [[1jnj|1jnj]], [[1agb|1agb]], [[2d31|2d31]], [[1aqd|1aqd]], [[1xz0|1xz0]], [[1lds|1lds]], [[1tvh|1tvh]], [[1hhh|1hhh]], [[1xr8|1xr8]], [[2bss|2bss]], [[1e28|1e28]], [[1a1m|1a1m]], [[2bvp|2bvp]], [[2v2x|2v2x]], [[1xr9|1xr9]], [[2gj6|2gj6]], [[1qlf|1qlf]], [[1efx|1efx]], [[2av1|2av1]], [[1tmc|1tmc]], [[1qsf|1qsf]], [[1duy|1duy]], [[1kpr|1kpr]], [[1jge|1jge]], [[2hjl|2hjl]], [[1qew|1qew]], [[1w0v|1w0v]], [[1k5n|1k5n]], [[1ao7|1ao7]], [[2bnr|2bnr]], [[1xh3|1xh3]], [[2bst|2bst]], [[1mi5|1mi5]], [[2h26|2h26]], [[1s9y|1s9y]], [[1a1o|1a1o]], [[2a83|2a83]], [[1agf|1agf]], [[1oga|1oga]], [[2f8o|2f8o]], [[2cii|2cii]], [[1i7r|1i7r]], [[1jf1|1jf1]], [[2c7u|2c7u]], [[1e27|1e27]], [[2f74|2f74]], [[1w0w|1w0w]], [[1gzq|1gzq]], [[1uxs|1uxs]], [[1akj|1akj]], [[2hjk|2hjk]], [[2vb5|2vb5]], [[1agd|1agd]], [[1r3h|1r3h]], [[1eey|1eey]], [[1i7t|1i7t]], [[1i4f|1i4f]], [[1ydp|1ydp]], [[2vll|2vll]], [[2bsr|2bsr]], [[2vlj|2vlj]], [[1b0r|1b0r]], [[1b0g|1b0g]], [[1of2|1of2]], [[1hhi|1hhi]], [[1qse|1qse]], [[2axg|2axg]], [[1a9b|1a9b]], [[2bvq|2bvq]], [[1agc|1agc]], [[1hhj|1hhj]], [[1qvo|1qvo]], [[1s9w|1s9w]], [[1ktl|1ktl]], [[1a6z|1a6z]], [[2cik|2cik]], [[2uwe|2uwe]], [[1i1f|1i1f]], [[2av7|2av7]], [[2x4r|2x4r]], [[2x4o|2x4o]], [[2x4u|2x4u]], [[2x4p|2x4p]], [[2x4q|2x4q]], [[2x4t|2x4t]], [[2x4n|2x4n]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4s OCA], [http://pdbe.org/2x4s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4s RCSB], [http://www.ebi.ac.uk/pdbsum/2x4s PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4s OCA], [http://pdbe.org/2x4s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4s RCSB], [http://www.ebi.ac.uk/pdbsum/2x4s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4s_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4s_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>

Revision as of 09:26, 3 October 2018

Crystal structure of MHC CLass I HLA-A2.1 bound to a peptide representing the epitope of the H5N1 (Avian Flu) Nucleoprotein

2x4s, resolution 2.55Å

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