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1wbx

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Revision as of 16:36, 11 April 2018

CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE

Structural highlights

1wbx is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1bii, 1bqh, 1bz9, 1cd1, 1ddh, 1ffn, 1ffo, 1ffp, 1fg2, 1fo0, 1fzj, 1fzk, 1fzm, 1fzo, 1g6r, 1g7p, 1g7q, 1hoc, 1inq, 1jpf, 1jpg, 1juf, 1k8d, 1kbg, 1kj2, 1kj3, 1kpu, 1kpv, 1l6q, 1ld9, 1ldp, 1leg, 1lek, 1lk2, 1mhc, 1mwa, 1n3n, 1n59, 1n5a, 1nam, 1nan, 1nez, 1osz, 1p1z, 1p4l, 1pqz, 1qo3, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1vac, 1vad, 2ckb, 2mha, 2vaa, 2vab, 1ce6, 1wby, 1wbz, 1qlf
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. [HEMA_I88A6] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Cytotoxic T lymphocyte (CTL) responses against influenza A virus in C57BL/6 mice are dominated by a small number of viral peptides among many that are capable of binding to major histocompatibility complex (MHC) class I molecules. The basis of this limited immune recognition is unknown. Here, we present X-ray structures of MHC class I molecules in complex with two immunodominant epitopes (PA(224-233)/D(b) and PB1(703-711)/K(b)) and one non-immunogenic epitope (HA(468-477)/D(b)) of the influenza A virus. The immunodominant peptides are each characterized by a bulge at the C terminus, lifting P6 and P7 residues out of the MHC groove, presenting featured structural elements to T-cell receptors (TCRs). Immune recognition of PA(224-233)/D(b) will focus largely on the exposed P7 arginine residue. In contrast, the non-immunogenic HA(468-477) peptide lacks prominent features in this C-terminal bulge. In the K(b)-bound PB1(703-711) epitope, the bulge results from a non-canonical binding motif, such that the mode of presentation of this peptide strongly resembles that of D(b)-bound peptides. Given that PA(224-233)/D(b), PB1(703-711)/K(b) and the previously defined NP(366-374)/D(b) epitopes dominate the primary response to influenza A virus in C57BL/6 mice, our findings indicate that residues of the C-terminal bulge are important in selection of the immunodominant CTL repertoire.

Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance.,Meijers R, Lai CC, Yang Y, Liu JH, Zhong W, Wang JH, Reinherz EL J Mol Biol. 2005 Feb 4;345(5):1099-110. Epub 2004 Dec 8. PMID:15644207^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Meijers R, Lai CC, Yang Y, Liu JH, Zhong W, Wang JH, Reinherz EL. Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance. J Mol Biol. 2005 Feb 4;345(5):1099-110. Epub 2004 Dec 8. PMID:15644207 doi:10.1016/j.jmb.2004.11.023

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wbx"

@@ Line 1: / Line 1: @@
-==CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 DB AND KB MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE==
+==CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE==
 <StructureSection load='1wbx' size='340' side='right' caption='[[1wbx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1wbx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WBX FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bii|1bii]], [[1bqh|1bqh]], [[1bz9|1bz9]], [[1cd1|1cd1]], [[1ddh|1ddh]], [[1ffn|1ffn]], [[1ffo|1ffo]], [[1ffp|1ffp]], [[1fg2|1fg2]], [[1fo0|1fo0]], [[1fzj|1fzj]], [[1fzk|1fzk]], [[1fzm|1fzm]], [[1fzo|1fzo]], [[1g6r|1g6r]], [[1g7p|1g7p]], [[1g7q|1g7q]], [[1hoc|1hoc]], [[1inq|1inq]], [[1jpf|1jpf]], [[1jpg|1jpg]], [[1juf|1juf]], [[1k8d|1k8d]], [[1kbg|1kbg]], [[1kj2|1kj2]], [[1kj3|1kj3]], [[1kpu|1kpu]], [[1kpv|1kpv]], [[1l6q|1l6q]], [[1ld9|1ld9]], [[1ldp|1ldp]], [[1leg|1leg]], [[1lek|1lek]], [[1lk2|1lk2]], [[1mhc|1mhc]], [[1mwa|1mwa]], [[1n3n|1n3n]], [[1n59|1n59]], [[1n5a|1n5a]], [[1nam|1nam]], [[1nan|1nan]], [[1nez|1nez]], [[1osz|1osz]], [[1p1z|1p1z]], [[1p4l|1p4l]], [[1pqz|1pqz]], [[1qo3|1qo3]], [[1s7q|1s7q]], [[1s7r|1s7r]], [[1s7s|1s7s]], [[1s7t|1s7t]], [[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[1vac|1vac]], [[1vad|1vad]], [[2ckb|2ckb]], [[2mha|2mha]], [[2vaa|2vaa]], [[2vab|2vab]], [[1ce6|1ce6]], [[1wby|1wby]], [[1wbz|1wbz]], [[1qlf|1qlf]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbx OCA], [http://pdbe.org/1wbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wbx RCSB], [http://www.ebi.ac.uk/pdbsum/1wbx PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbx OCA], [http://pdbe.org/1wbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wbx RCSB], [http://www.ebi.ac.uk/pdbsum/1wbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbx ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wbx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wbx_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

1wbx

From Proteopedia

Revision as of 16:36, 11 April 2018

CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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