3f6k
From Proteopedia
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==Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin== | ==Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin== | ||
<StructureSection load='3f6k' size='340' side='right' caption='[[3f6k]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3f6k' size='340' side='right' caption='[[3f6k]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3f6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F6K FirstGlance]. <br> | <table><tr><td colspan='2'>[[3f6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F6K FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f6k OCA], [http://pdbe.org/3f6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f6k RCSB], [http://www.ebi.ac.uk/pdbsum/3f6k PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f6k OCA], [http://pdbe.org/3f6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f6k RCSB], [http://www.ebi.ac.uk/pdbsum/3f6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f6k ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/3f6k_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/3f6k_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3f6k" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3f6k" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Neurotensin receptor|Neurotensin receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 21:56, 2 December 2018
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin
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Categories: Human | Groftehauge, M K | Madsen, P | Nissen, P | Petersen, C M | Quistgaard, E M | Thirup, S | 10-bladed beta-propeller | Cys-rich domain | Cytoplasmic vesicle | Developmental protein | Differentiation | Endocytosis | Endoplasmic reticulum | Endosome | Glycoprotein | Golgi apparatus | Lysosome | Membrane | Phosphoprotein | Protein sorting receptor | Protein-peptide complex | Receptor | Secreted | Signaling protein | Sortilin vps10p-d | Ssortilin | Transmembrane | Transport
