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Sandbox Wabash13
From Proteopedia
(Difference between revisions)
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| - | Trypsin Structure - Chase Francoeur | + | Trypsin Structure - Chase Francoeur, Elias Arellano |
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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== Function == | == Function == | ||
Trypsin is a serine protease released by the pancreas and secreted into the duodenum that acts as a digestive enzyme that catalyzes the hydrolysis of peptide bonds, specifically for positively charged residues (K, R, H). The mechanism in which the enzyme acts as a protease is as follows: | Trypsin is a serine protease released by the pancreas and secreted into the duodenum that acts as a digestive enzyme that catalyzes the hydrolysis of peptide bonds, specifically for positively charged residues (K, R, H). The mechanism in which the enzyme acts as a protease is as follows: | ||
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1. Nucleophillic and base catalysis by enzyme to substrate to form tetrahedral intermediate at carbonyl group of scissile peptide. | 1. Nucleophillic and base catalysis by enzyme to substrate to form tetrahedral intermediate at carbonyl group of scissile peptide. | ||
2. Acid catalysis breaks the tetrahedral intermediate through cleaving of the scissile peptide bond to form an acyl-enzyme intermediate. | 2. Acid catalysis breaks the tetrahedral intermediate through cleaving of the scissile peptide bond to form an acyl-enzyme intermediate. | ||
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== Relevance == | == Relevance == | ||
| - | == Structural highlights == | + | == Structural highlights of Trypsin == |
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| + | <scene name='72/725338/Ribbon_diagram_n_c_rainbow/1'>Ribbon Diagram of Trypsin (N-->C Rainbow)</scene> | ||
| - | <scene name=' | + | <scene name='Sandbox_45/Ctriadd102h57s195/4'>catalytic triad</scene> |
<scene name='72/725338/Serine__195/1'>Serine 195 - Base Catalysis Residue</scene> | <scene name='72/725338/Serine__195/1'>Serine 195 - Base Catalysis Residue</scene> | ||
Revision as of 23:11, 18 February 2016
Trypsin Structure - Chase Francoeur, Elias Arellano
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