Dipeptidyl peptidase
From Proteopedia
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[[Dipeptidyl peptidase]] (DPP) is an enzyme which cleaves dipeptides from polypeptides.<br /> | [[Dipeptidyl peptidase]] (DPP) is an enzyme which cleaves dipeptides from polypeptides.<br /> | ||
| - | * '''DPP-I''' | + | * '''DPP-I''' see [[Cathepsin]] C is involved in inflammatory diseases.<br /> |
* '''DPP-II''' is a serine protease.<br /> | * '''DPP-II''' is a serine protease.<br /> | ||
* '''DPP-III''' acts similarly to DPP-IV.<br /> | * '''DPP-III''' acts similarly to DPP-IV.<br /> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *DPP-I | + | *DPP-I see [[Cathepsin]] C. |
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*DPP-II | *DPP-II | ||
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*DPP-III | *DPP-III | ||
| - | **[[3fvy]] – hDPP-III<br /> | + | **[[3fvy]], [[5egy]] – hDPP-III<br /> |
**[[3t6b]], [[3t6j]] - hDPP-III (mutant) + tynorphin<br /> | **[[3t6b]], [[3t6j]] - hDPP-III (mutant) + tynorphin<br /> | ||
| + | **[[5e2q]] - hDPP-III (mutant) + angiotensin II<br /> | ||
| + | **[[5e33]], [[5e3a]] - hDPP-III (mutant) + enkephalin <br /> | ||
| + | **[[5e3c]] - hDPP-III (mutant) + opioid peptide<br /> | ||
| + | **[[5ehh]] - hDPP-III (mutant) + endomorphin II<br /> | ||
**[[3csk]] – DPP-III (mutant) – yeast<br /> | **[[3csk]] – DPP-III (mutant) – yeast<br /> | ||
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**[[1u8e]] – hDPP-IV extracellular domain (mutant)<br /> | **[[1u8e]] – hDPP-IV extracellular domain (mutant)<br /> | ||
**[[3kwj]], [[3oc0]], [[3kwf]], [[3q8w]] – hDPP-IV extracellular domain +quinoline derivative<br /> | **[[3kwj]], [[3oc0]], [[3kwf]], [[3q8w]] – hDPP-IV extracellular domain +quinoline derivative<br /> | ||
| - | **[[3g0b]], [[3g0d]], [[3g0g]], [[3nox]], [[3hab]], [[3hac]], [[3f8s]], [[3h0c]], [[3ccb]], [[3ccc]], [[2qjr]], [[2qky]], [[3d4l]], [[2jid]], [[3bjm]], [[2rip]], [[2ole]], [[2rgu]], [[2i78]], [[2oag]], [[2oqv]], [[2oqi]], [[2ogz]], [[2i03]], [[2g5p]], [[2g5t]], [[2g63]], [[2bub]], [[2ajl]], [[1wcy]], [[1rwq]], [[1tkr]], [[1n1m]], [[3eio]], [[3g0c]], [[3opm]], [[3sww]], [[3sx4]], [[3q0t]], [[4a5s]], [[3vjk]], [[3vjl]], [[3vjm]], [[3w2t]], [[4dsa]], [[4dsz]], [[4dtc]], [[4g1f]],[[3o95]], [[3o9v]], [[4j3j]], [[4jh0]], [[4lko]], [[4n8d]], [[4n8e]], [[4pnz]], [[4pv7]] – hDPP-IV extracellular domain+inhibitor<br /> | + | **[[3g0b]], [[3g0d]], [[3g0g]], [[3nox]], [[3hab]], [[3hac]], [[3f8s]], [[3h0c]], [[3ccb]], [[3ccc]], [[2qjr]], [[2qky]], [[3d4l]], [[2jid]], [[3bjm]], [[2rip]], [[2ole]], [[2rgu]], [[2i78]], [[2oag]], [[2oqv]], [[2oqi]], [[2ogz]], [[2i03]], [[2g5p]], [[2g5t]], [[2g63]], [[2bub]], [[2ajl]], [[1wcy]], [[1rwq]], [[1tkr]], [[1n1m]], [[3eio]], [[3g0c]], [[3opm]], [[3sww]], [[3sx4]], [[3q0t]], [[4a5s]], [[3vjk]], [[3vjl]], [[3vjm]], [[3w2t]], [[4dsa]], [[4dsz]], [[4dtc]], [[4g1f]],[[3o95]], [[3o9v]], [[4j3j]], [[4jh0]], [[4lko]], [[4n8d]], [[4n8e]], [[4pnz]], [[4pv7]], [[3wqh]], [[5i7u]], [[5j3j]], [[5kby]], [[5t4b]], [[5t4e]], [[5t4f]], [[5t4h]] – hDPP-IV extracellular domain+inhibitor<br /> |
**[[1r9n]], [[2bgr]], [[1nu8]] – hDPP-IV extracellular domain+polypeptide<br /> | **[[1r9n]], [[2bgr]], [[1nu8]] – hDPP-IV extracellular domain+polypeptide<br /> | ||
**[[1w1i]] – hDPP-IV extracellular domain+adenosine deaminase<br /> | **[[1w1i]] – hDPP-IV extracellular domain+adenosine deaminase<br /> | ||
**[[2bgn]] – hDPP-IV extracellular domain+adenosine deaminase+polypeptide<br /> | **[[2bgn]] – hDPP-IV extracellular domain+adenosine deaminase+polypeptide<br /> | ||
| - | **[[3c43]], [[3c45]], [[2qoe]], [[2qt9]], [[2qtb]], [[2p8s]], [[2oph]], [[2fjp]], [[1x70]], [[2iit]], [[2iiv]], [[3qbj]] – hDPP-IV extracellular domain (mutant) + inhibitor <br /> | + | **[[3c43]], [[3c45]], [[2qoe]], [[2qt9]], [[2qtb]], [[2p8s]], [[2oph]], [[2fjp]], [[1x70]], [[2iit]], [[2iiv]], [[3qbj]], [[5ism]] – hDPP-IV extracellular domain (mutant) + inhibitor <br /> |
**[[4kr0]], [[4qzv]] - hDPP-IV extracellular domain + S protein<br /> | **[[4kr0]], [[4qzv]] - hDPP-IV extracellular domain + S protein<br /> | ||
**[[4l72]] – rDPP-IV + Mers-Cov Rbd<br /> | **[[4l72]] – rDPP-IV + Mers-Cov Rbd<br /> | ||
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**[[2oae]], [[2i3z]], [[2gbf]], [[2gbg]], [[2gbi]] – rDPP-IV extracellular domain+inhibitor<br /> | **[[2oae]], [[2i3z]], [[2gbf]], [[2gbg]], [[2gbi]] – rDPP-IV extracellular domain+inhibitor<br /> | ||
**[[4ffv]], [[4ffw]] – rDPP-IV + antibody<br /> | **[[4ffv]], [[4ffw]] – rDPP-IV + antibody<br /> | ||
| - | **[[2aj8]], [[2ajb]], [[2ajc]], [[2ajd]], [[2bua]], [[2buc]], [[1orw]] – pDPP-IV extracellular domain+inhibitor - pig<br /> | + | **[[2aj8]], [[2ajb]], [[2ajc]], [[2ajd]], [[2bua]], [[2buc]], [[1orw]], [[5lls]] – pDPP-IV extracellular domain+inhibitor - pig<br /> |
**[[1orv]] - pDPP-IV extracellular domain<br /> | **[[1orv]] - pDPP-IV extracellular domain<br /> | ||
**[[2ecf]] - DPP-IV – ''Stenotrophomonas maltophilia'' | **[[2ecf]] - DPP-IV – ''Stenotrophomonas maltophilia'' | ||
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**[[4wjl]] – hDPP-X extracellular domain<br /> | **[[4wjl]] – hDPP-X extracellular domain<br /> | ||
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| + | *DPP-XI or peptidase S46 | ||
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| + | **[[4xzy]], [[4y01]], [[4y02]], [[4y04]] – hDPP-XI – ''Porphyromonas gingivalis''<br /> | ||
}} | }} | ||
Revision as of 08:41, 23 April 2017
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3D Structures of Dipeptidyl peptidase
Updated on 23-April-2017
References
- ↑ Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer. Histol Histopathol. 2004 Oct;19(4):1345-51. PMID:15375776
- ↑ Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract. 2006 Nov;60(11):1454-70. PMID:17073841 doi:10.1111/j.1742-1241.2006.01178.x
- ↑ Itou M, Kawaguchi T, Taniguchi E, Sata M. Dipeptidyl peptidase-4: a key player in chronic liver disease. World J Gastroenterol. 2013 Apr 21;19(15):2298-306. doi:, 10.3748/wjg.v19.i15.2298. PMID:23613622 doi:http://dx.doi.org/10.3748/wjg.v19.i15.2298
- ↑ Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K. Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. J Med Chem. 2014 Mar 14. PMID:24592859 doi:http://dx.doi.org/10.1021/jm401705g
