User:Gisselle Medina/Sandbox7 Leader

==Introduction==

==Introduction==

<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'

<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'

==Structure==

==Structure==

The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.

The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.

Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.