Glucagon

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{{STRUCTURE_1bh0| PDB=1bh0 | SIZE=350| SCENE= |right|CAPTION=Human glucagon, [[1bh0]] }}
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<StructureSection load='1bh0' size='350' side='right' caption='Structure of human glucagon (PDB entry [[1bh0]])' scene=''>
== Function ==
== Function ==
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Glucagon is injected in cases of severe glycemia<ref>PMID:15793249</ref>. Overdose of β blockers is treated with GLCas well as cases of Epinephrin-resistant low blood pressure. Pancreatic tumors may cause high levels of GLC.
Glucagon is injected in cases of severe glycemia<ref>PMID:15793249</ref>. Overdose of β blockers is treated with GLCas well as cases of Epinephrin-resistant low blood pressure. Pancreatic tumors may cause high levels of GLC.
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</StructureSection>
== 3D Structures of glucagon ==
== 3D Structures of glucagon ==

Revision as of 09:14, 24 May 2017

Structure of human glucagon (PDB entry 1bh0)

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3D Structures of glucagon

Updated on 24-May-2017

2g49 – hGLC preprotein residues 53-81+ insulin-degrading enzyme – human
1kx6, 2m5p, 2m5q – hGLC - NMR
1nau – hGLC (mutant) – NMR
1bh0 - hGLC (mutant)
1gcn - hGLC

References

  1. ↑ Ramnanan CJ, Edgerton DS, Kraft G, Cherrington AD. Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab. 2011 Oct;13 Suppl 1:118-25. doi:, 10.1111/j.1463-1326.2011.01454.x. PMID:21824265 doi:http://dx.doi.org/10.1111/j.1463-1326.2011.01454.x
  2. ↑ Heptulla RA, Rodriguez LM, Bomgaars L, Haymond MW. The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes. Diabetes. 2005 Apr;54(4):1100-7. PMID:15793249

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Karsten Theis, Ann Taylor

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