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Introduction

The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as G protein-coupled receptors and responds to the 13 amino acid hormone nuerotensin (NT). There are currently around 800 G protein-coupled receptors that have been identified and are thought to be responsible for roughly 80% of signal transduction across the cell membrane.(reference (year in g protein) These receptors are involved in a vast array of physiological processes within the body and are a major site of drug targets in medicine. (reference 5 main families)

Neurotensin

Structure

Overall Structure

Like all other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein, a region containing 7 transmembrane alpha helices that transduce the signal from the extracellular side of the cell membrane to the intracellular side, and an intracellular region that when activated by a conformational change in the protein activates a G protein associated with this receptor.

Neurotensin Binding Site

Hydrophobic Stacking

Sodium Binding Pocket

Allosteric Effects

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.