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Methyl CpG binding protein

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**[[2l2l]] - hMBD2 coiled-coil domain + transcriptional repressor p66-α coiled-coil domain – NMR<br />
**[[2l2l]] - hMBD2 coiled-coil domain + transcriptional repressor p66-α coiled-coil domain – NMR<br />
 +
**[[5bt2]] – hMBD2 MBD + methylated DNA <br />
**[[2ky8]] – cMBD2 MBD domain + DNA containing cytidine and uridine derivatives - NMR - chicken<br />
**[[2ky8]] – cMBD2 MBD domain + DNA containing cytidine and uridine derivatives - NMR - chicken<br />
Line 52: Line 53:
**[[3vxv]], [[3vxx]], [[3vyb]], [[3vyq]] – mMBD4 MBD + DNA containing cytidine derivative<br />
**[[3vxv]], [[3vxx]], [[3vyb]], [[3vyq]] – mMBD4 MBD + DNA containing cytidine derivative<br />
**[[4lg7]], [[2moe]] – hMBD4 MBD + DNA containing cytidine derivative<br />
**[[4lg7]], [[2moe]] – hMBD4 MBD + DNA containing cytidine derivative<br />
 +
**[[5chz]] – hMBD4 MBD + DNA containing mismatch<br />
**[[4ofa]], [[4ofe]], [[4ofh]] – hMBD4 MBD (mutant) + DNA containing mismatch<br />
**[[4ofa]], [[4ofe]], [[4ofh]] – hMBD4 MBD (mutant) + DNA containing mismatch<br />

Revision as of 08:57, 20 July 2017

Structure of mouse MBD4 glycosylate domain complex with DNA containing mismatch, ethylene glycol and Ni+2 ion (green) (PDB code 4evv).

Drag the structure with the mouse to rotate

3D structures of methyl CpG binding protein

Updated on 20-July-2017

References

  1. ↑ Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:http://dx.doi.org/10.1002/bies.10008
  2. ↑ Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
  3. ↑ Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res. 2012 Jun 27. PMID:22740654 doi:10.1093/nar/gks628

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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