5lho
From Proteopedia
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lho OCA], [http://pdbe.org/5lho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lho RCSB], [http://www.ebi.ac.uk/pdbsum/5lho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lho ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lho OCA], [http://pdbe.org/5lho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lho RCSB], [http://www.ebi.ac.uk/pdbsum/5lho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lho ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | 14-3-3 proteins bind phosphorylated binding partners to regulate several of their properties, including enzymatic activity, stability and subcellular localization. Here, two crystal structures are presented: the crystal structures of the 14-3-3 protein (also known as Bmh1) from the yeast Lachancea thermotolerans in the unliganded form and bound to a phosphopeptide derived from human PI4KB (phosphatidylinositol 4-kinase B). The structures demonstrate the high evolutionary conservation of ligand recognition by 14-3-3 proteins. The structural analysis suggests that ligand recognition by 14-3-3 proteins evolved very early in the evolution of eukaryotes and remained conserved, underlying the importance of 14-3-3 proteins in physiology. | ||
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| + | Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation.,Eisenreichova A, Klima M, Boura E Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):799-803. Epub 2016, Oct 24. PMID:27827352<ref>PMID:27827352</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5lho" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 14:28, 22 December 2016
Crystal structure of yeast 14-3-3 protein (Bmh1) from Lachancea thermotolerans
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Categories: Boura, E | Klima, M | 14-3-3 | Bmh1 | Signaling protein
