3umv

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==Eukaryotic Class II CPD photolyase structure reveals a basis for improved UV-tolerance in plants==
==Eukaryotic Class II CPD photolyase structure reveals a basis for improved UV-tolerance in plants==
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<StructureSection load='3umv' size='340' side='right' caption='[[3umv]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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<StructureSection load='3umv' size='340' side='right'caption='[[3umv]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3umv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Japanese_rice Japanese rice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UMV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3umv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Japanese_rice Japanese rice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UMV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHR, Os10g0167600, LOC_Os10g08580, OSJNAb0015J03.12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39947 Japanese rice])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHR, Os10g0167600, LOC_Os10g08580, OSJNAb0015J03.12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39947 Japanese rice])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribodipyrimidine_photo-lyase Deoxyribodipyrimidine photo-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.3 4.1.99.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deoxyribodipyrimidine_photo-lyase Deoxyribodipyrimidine photo-lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.3 4.1.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3umv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3umv OCA], [http://pdbe.org/3umv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3umv RCSB], [http://www.ebi.ac.uk/pdbsum/3umv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3umv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3umv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3umv OCA], [https://pdbe.org/3umv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3umv RCSB], [https://www.ebi.ac.uk/pdbsum/3umv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3umv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PHR_ORYSJ PHR_ORYSJ]] Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Required for plant survival in the presence of UV-B light. Not involved in the repair of (6-4) photoproducts.<ref>PMID:12764611</ref> <ref>PMID:15965242</ref> <ref>PMID:17895582</ref> <ref>PMID:17397507</ref> <ref>PMID:18235036</ref> <ref>PMID:20227927</ref>
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[[https://www.uniprot.org/uniprot/PHR_ORYSJ PHR_ORYSJ]] Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Required for plant survival in the presence of UV-B light. Not involved in the repair of (6-4) photoproducts.<ref>PMID:12764611</ref> <ref>PMID:15965242</ref> <ref>PMID:17895582</ref> <ref>PMID:17397507</ref> <ref>PMID:18235036</ref> <ref>PMID:20227927</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Deoxyribodipyrimidine photo-lyase]]
[[Category: Deoxyribodipyrimidine photo-lyase]]
[[Category: Japanese rice]]
[[Category: Japanese rice]]
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[[Category: Large Structures]]
[[Category: Arvai, A S]]
[[Category: Arvai, A S]]
[[Category: Getzoff, E D]]
[[Category: Getzoff, E D]]

Revision as of 07:48, 20 July 2022

Eukaryotic Class II CPD photolyase structure reveals a basis for improved UV-tolerance in plants

PDB ID 3umv

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