This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4q1e
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}== | ==Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}== | ||
| - | <StructureSection load='4q1e' size='340' side='right' caption='[[4q1e]], [[Resolution|resolution]] 1.85Å' scene=''> | + | <StructureSection load='4q1e' size='340' side='right'caption='[[4q1e]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4q1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4q1e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1E FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Y7:(S)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5-METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE'>2Y7</scene>, <scene name='pdbligand=2Y8:(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5-METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE'>2Y8</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Y7:(S)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5-METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE'>2Y7</scene>, <scene name='pdbligand=2Y8:(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5-METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE'>2Y8</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q18|4q18]], [[4q19|4q19]], [[4q1a|4q1a]], [[4q1b|4q1b]], [[4q1c|4q1c]], [[4q1d|4q1d]], [[4q1f|4q1f]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q18|4q18]], [[4q19|4q19]], [[4q1a|4q1a]], [[4q1b|4q1b]], [[4q1c|4q1c]], [[4q1d|4q1d]], [[4q1f|4q1f]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1e OCA], [http://pdbe.org/4q1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1e RCSB], [http://www.ebi.ac.uk/pdbsum/4q1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1e ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1e OCA], [http://pdbe.org/4q1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1e RCSB], [http://www.ebi.ac.uk/pdbsum/4q1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1e ProSAT]</span></td></tr> | ||
| Line 28: | Line 29: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Deoxycytidine kinase]] | [[Category: Deoxycytidine kinase]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lavie, A]] | [[Category: Lavie, A]] | ||
[[Category: Nomme, J]] | [[Category: Nomme, J]] | ||
Revision as of 07:53, 17 April 2019
Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}
| |||||||||||
