Rhomboid protease
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xow' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene=''> | <StructureSection load='2xow' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | + | '''Rhomboid protease''' (GlpG) is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. |
== Structural highlights == | == Structural highlights == | ||
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**[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | **[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | ||
| - | **[[2xtu]], [[3b44]], [[2xtv]] – EcGlpG core region (mutant) <BR /> | + | **[[2xtu]], [[3b44]], [[2xtv]], [[5f5d]] – EcGlpG core region (mutant) <BR /> |
**[[4hdd]] – EcGlpG N terminal <BR /> | **[[4hdd]] – EcGlpG N terminal <BR /> | ||
**[[2lep]], [[2mja]] – EcGlpG N terminal - NMR <BR /> | **[[2lep]], [[2mja]] – EcGlpG N terminal - NMR <BR /> | ||
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**[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | **[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | ||
**[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | **[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | ||
| + | **[[5f5j]], [[5f5k]] – EcGlpG core region (mutant) + aldehyde inhibitor <BR /> | ||
**[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | **[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | ||
| - | **[[4qo0]], [[4qo2]] – EcGlpG core region + peptide inhibitor <BR /> | + | **[[4qo0]], [[4qo2]], [[5f5g]], [[5f5b]] – EcGlpG core region + peptide inhibitor <BR /> |
}} | }} | ||
Revision as of 07:51, 10 August 2016
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3D Structures of rhomboid protease
Updated on 10-August-2016
References
- ↑ Freeman M. Rhomboid proteases and their biological functions. Annu Rev Genet. 2008;42:191-210. doi: 10.1146/annurev.genet.42.110807.091628. PMID:18605900 doi:http://dx.doi.org/10.1146/annurev.genet.42.110807.091628
- ↑ Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M. The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J. 2010 Oct 1. PMID:20890268 doi:10.1038/emboj.2010.243
