Spermidine/spermine N-acetyltransferase
From Proteopedia
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| - | + | <StructureSection load='2jev' size='450' side='right' scene='' caption='Human SSAT1 dimer complex with acetyl-spermine-S-CoA, [[2jev]]'> | |
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== Function == | == Function == | ||
'''Spermidine/spermine N-acetyltransferase''' (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | '''Spermidine/spermine N-acetyltransferase''' (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
The active site of SSAT contains a bisubstrate inhibitor. In catalysis, residues Tyr140 act as general acid and Glu92 as general base<ref>PMID:17516632</ref>. | The active site of SSAT contains a bisubstrate inhibitor. In catalysis, residues Tyr140 act as general acid and Glu92 as general base<ref>PMID:17516632</ref>. | ||
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==3D structures of SSAT== | ==3D structures of SSAT== | ||
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Revision as of 07:20, 4 September 2016
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3D structures of SSAT
04-September-2016
References
- ↑ Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E995-1010. doi:, 10.1152/ajpendo.90217.2008. Epub 2008 Mar 18. PMID:18349109 doi:http://dx.doi.org/10.1152/ajpendo.90217.2008
- ↑ Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA Jr, Johnston PG. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther. 2007 Jan;6(1):128-37. PMID:17237273 doi:http://dx.doi.org/10.1158/1535-7163.MCT-06-0303
- ↑ Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. Epub 2007 May 22. PMID:17516632 doi:10.1021/bi700256z
