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Virus protease

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See also<br />
See also<br />
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*[[Immunodeficiency virus protease]]<br />
*[[Human Immunodeficiency Virus]]<br />
*[[Human Immunodeficiency Virus]]<br />
*[[HIV-1 protease]]<br />
*[[HIV-1 protease]]<br />
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''HIV-1 protease'''
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*'''HIV-1 protease''' . See [[Immunodeficiency virus protease]]
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**[[3ixo]] - HIV1-PR subtype A<br />
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*'''HIV-2 protease''' See [[Immunodeficiency virus protease]]
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**[[1odx]], [[2hb2]], [[2hb4]], [[2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br />
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**[[1rpi]], [[1rq9]], [[1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] - HIV1-PR (drug-resistant mutant) <br />
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**[[1odw]], [[4e43]], [[3hvp]], [[3phv]] - HIV1-PR<br />
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**[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer
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*HIV-1 protease complexes
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*'''Feline Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
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**[[1hsg]], [[1hsh]], [[1hsi]], [[3oxc]], [[3ekv]], [[3ekx]], [[3eky]], [[3el1]], [[1ohr]], [[3ndt]], [[3nls]], [[4ll3]], [[3ndu]], [[3ndw]], [[3ndx]], [[3r0w]], [[3r0y]], [[4dqb]], [[4jec]], [[4hla]] - HIV1-PR + antiviral drug<br />
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**[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br />
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**[[1aid]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]], [[3mxe]], [[3m9f ]], [[3kf0]], [[3kf1]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[2wkz]], [[2wl0]], [[3gga]], [[3ggv]], [[3ggx]], [[2uxz]], [[2uy0]], [[1zp8]], [[1xl2]], [[1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[7upj]], [[1hxb]], [[1hih]], [[1hvr]], [[1hef]], [[1heg]], [[4phv]], [[1w5w]], [[1w5x]], [[1w5v]], [[1w5y]], [[1t7k]], [[1npa]], [[1npv]], [[1npw]], [[1eby]], [[1ec0]], [[1g2k]], [[1c6x]], [[1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[1hvh]], [[3tlh]], [[1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br />
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**[[2zye]] - HIV1-PR + inhibitor - neutron<br />
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**[[3aid]], [[1ytg]], [[1yth]], [[2nxd]], [[2nxl]], [[2nxm]], [[2fns]], [[2fnt]], [[1zj7]], [[1zlf]], [[1zpk]], [[1zsf]], [[1zsr]], [[1cpi]], [[1m0b]], [[1iiq]], [[1fqx]], [[1a30]] - HIV1-PR + polypeptide derivative<br />
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**[[3gi0]] - HIV1-PR covalent dimer + polypeptide<br />
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**[[3hzc]], [[3iaw]], [[3ka2]], [[3nxn]] - HIV1-PR covalent dimer + inhibitor<br />
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**[[1sp5]] - HIV1-PR + autoproteolytic peptide<br />
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**[[4ep2]], [[4epj]], [[4eq0]], [[4eqj]] - HIV1-PR + substrate<br />
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**[[4ejd]], [[4ejk]] - HIV1-PR + pepstatin<br />
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**[[4f73]]- HIV1-PR + CA-P2<br />
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**[[4f74]]- HIV1-PR + MA-CA<br />
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**[[4f75]]- HIV1-PR + RH-IN<br />
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**[[4f76]]- HIV1-PR + P1-P6<br />
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*HIV-1 protease (mutant) complexes
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**[[3nu3]], [[3nu4]], [[3nu5]], [[3nu6]], [[3nu9]], [[3nuj]], [[3nuo]], [[2qhc]], [[2qak]], [[2pym]], [[2pyn]], [[2q63]], [[2q64]], [[2fxd]], [[2fxe]], [[2fgu]], [[2fgv]], [[1sdt]], [[1sdu]], [[1sdv]], [[1d4y]], [[1d4s]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1y]], [[3d1z]], [[3d20]], [[3djk]], [[3dk1]], [[3n3i]], [[3oxv]], [[3oxw]], [[3oxx]], [[3oy4]], [[3k4v]], [[3lzs]], [[3lzu]], [[3lzv]], [[3so9]], [[3spk]], [[3ufn]], [[4dqh]], [[3s43]], [[3s53]], [[3s54]], [[3s56]], [[4dqc]], [[4dqe]], [[4dqf]], [[4dqg]] - HIV1-PR (mutant) + antiviral drug<br />
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**[[2aid]], [[1hpo]], [[1tcx]], [[1gnm]], [[1gnn]], [[1gno]], [[1kzk]], [[3ok9]], [[3i8w]], [[3i7e]], [[3bxr]], [[3bxs]], [[2hc0]], [[2psu]], [[2psv]], [[2fle]], [[2f3k]], [[2ien]], [[2fdd]], [[2fde]], [[1t7i]], [[1t3r]], [[1mrw]], [[1mrx]], [[1msm]], [[1msn]], [[1bv9]], [[3h5b]], [[3kdb]], [[3kdc]], [[3kdd]], [[3a2o]], [[3bc4]], [[3fx5]], [[3i6o]], [[3st5]], [[3qaa]], [[3qbf]], [[3qih]], [[3qn8]], [[3qp0]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[4dfg]] - HIV1-PR (mutant) + inhibitor<br />
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**[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
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**[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
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**[[1zbg]], [[1z8c]], [[2az9]], [[2azc]], [[2a1e]], [[1lzq]], [[1d4k]], [[1d4l]], [[1a8k]], [[1a94]], [[1axa]], [[3dox]], [[3d3t]], [[4fl8]] - HIV1-PR (mutant) + polypeptide derivative<br />
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**[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane<br />
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**[[3b7v]], [[3b80]], [[3mim]] - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate<br />
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**[[3nxe]] - HIV1-PR covalent dimer (mutant) + inhibitor<br />
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**[[4flg]], [[4fm6]] - HIV1-PR (mutant) + reaction intermediate
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*HIV-1 protease (drug-resistant mutant) complexes
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**[[3el4]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[3u7s]], [[3ggu]], [[1t7j]], [[1rv7]], [[1n49]], [[1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]], [[3ucb]], [[3uhl]], [[3ttp]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
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**[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br />
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**[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
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**[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
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**[[2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor<br />
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*'''HIV-2 protease'''
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**[[1jld]] - HIV2-PR<br />
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**[[1hii]] - HIV2-PR + inhibitor<br />
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**[[5upj]], [[ 6upj]], [[ 3upj]], [[ 4upj]] - HIV2-PR (mutant) + inhibitor<br />
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**[[1ida]], [[ 1idb]], [[ 2mip]] - HIV2-PR + polypeptide derivative
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*'''Feline Immunodeficiency virus protease'''
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**[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
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**[[3ogp]], [[3ogq]] - FIV-PR residues 39-154 (mutant) + drug<br />
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**[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
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**[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
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*'''Simian Immunodeficiency virus protease'''
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**[[2sam]] - SIV-PR + inhibitor<br />
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*'''Simian Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
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**[[1az5]] - SIV-PR (mutant)<br />
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*'''Xenotropic murine leukemia virus protease'''
*'''Xenotropic murine leukemia virus protease'''

Revision as of 07:53, 18 July 2017

Template:STRUCTURE 1odw

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. See also

3D Structures of Virus proteases

Updated on 18-July-2017

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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