Resolvase
From Proteopedia
(Difference between revisions)
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<StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' > | <StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' > | ||
== Function == | == Function == | ||
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**[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br /> | **[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br /> | ||
**[[4ep5]] – TtHJR RuvC (mutant)<br /> | **[[4ep5]] – TtHJR RuvC (mutant)<br /> | ||
| - | **[[1zp7]] – | + | **[[1zp7]] – BsHJR RecU – ''Bacillus subtilis''<br /> |
| - | **[[1ob8]], [[1ob9]], [[1hh1]] – SsHJR – ''Sulfolobus solfataricus''<br /> | + | **[[5fdk]] - BsHJR RecU (mutant) + DNA<br /> |
| + | **[[1ob8]], [[1ob9]], [[1hh1]], [[2eo0]] – SsHJR – ''Sulfolobus solfataricus''<br /> | ||
| + | **[[4tkd]], [[4tkk]] - SsHJR (mutant) - <br /> | ||
**[[2fco]] – HJR – ''Geobacillus kaustophilus''<br /> | **[[2fco]] – HJR – ''Geobacillus kaustophilus''<br /> | ||
| - | **[[1ipi]], [[1gef]] – | + | **[[1ipi]], [[1gef]] – PfHJR – ''Pyrococcus furiosus''<br /> |
**[[1kcf]] – HJR – fission yeast<br /> | **[[1kcf]] – HJR – fission yeast<br /> | ||
| + | **[[1bvs]] - RuvA - ''Mycobacterium leprae''<br /> | ||
| + | **[[5e6f]] - HJR - canarypox virus<br /> | ||
* Ser-recombinase | * Ser-recombinase | ||
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**[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br /> | **[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br /> | ||
**[[2gm5]] – EcGDR (mutant)<br /> | **[[2gm5]] – EcGDR (mutant)<br /> | ||
| - | **[[3guv]] – site-specific recombinase – ''Streptococcus pneumoniae''<br /> | + | **[[3guv]] – Sp-site-specific recombinase – ''Streptococcus pneumoniae''<br /> |
| - | **[[2r0q]] – | + | **[[2r0q]] – SaS-rec+DNA – ''Staphylococcus aureus''<br /> |
| + | **[[3pkz]] - SaS-sin (mutant)<br /> | ||
**[[3lhf]] – SsS-rec<br /> | **[[3lhf]] – SsS-rec<br /> | ||
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**[[2f1i]] – MvRec+AMPPNP<br /> | **[[2f1i]] – MvRec+AMPPNP<br /> | ||
**[[2f1j]], [[2fpk]] - MvRec+ADP<br /> | **[[2f1j]], [[2fpk]] - MvRec+ADP<br /> | ||
| - | **[[1a0p]] – | + | **[[1a0p]] – EcXerD Rec<br /> |
| + | **[[5dcf]] - EcXerD C-terminal/FTSK<br /> | ||
| + | **[[5hxy]] - XerD - ''Thermoplasma acidophilum''<br /> | ||
| + | **[[5jjv]], [[5jk0]] - XerH - ''Helicobacter pylori''<br /> | ||
* Cre recombinase | * Cre recombinase | ||
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**[[4dc9]] – MvRadA C-terminal domain <br /> | **[[4dc9]] – MvRadA C-terminal domain <br /> | ||
**[[2i1q]] – MvRadA (mutant) <br /> | **[[2i1q]] – MvRadA (mutant) <br /> | ||
| - | **[[1pzn]] – PfRadA <br /> | + | **[[1pzn]], [[5fos]], [[5fot]], [[5fou]], [[5fox]], [[5fpk]], [[5fov]], [[5fow]] – PfRadA <br /> |
**[[4a6p]] – PfRadA ATPase domain (mutant) <br /> | **[[4a6p]] – PfRadA ATPase domain (mutant) <br /> | ||
| + | **[[5lkq]] - SpRadA protease domain<br /> | ||
| + | **[[5j4l]], [[5jec]], [[5jed]], [[5jee]], [[5kdd]], [[5l8v]], [[5lb2]], [[5lb4]], [[5lbi]], [[5jfg]] - PfRadA (mutant)<br /> | ||
| + | **[[5h45]] - TtRadA C-terminal<br /> | ||
*RadA recombinase complex | *RadA recombinase complex | ||
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**[[4b32]], [[4b33]] – PfRadA ATPase domain (mutant) + naphthol <br /> | **[[4b32]], [[4b33]] – PfRadA ATPase domain (mutant) + naphthol <br /> | ||
**[[4b34]] – PfRadA ATPase domain (mutant) + aminobenzothiazole <br /> | **[[4b34]] – PfRadA ATPase domain (mutant) + aminobenzothiazole <br /> | ||
| - | **[[4b3c]], [[4b3d]] – PfRadA ATPase domain (mutant) + indole <br /> | + | **[[4b3c]], [[4b3d]], [[5j4h]], [[5j4k]] – PfRadA ATPase domain (mutant) + indole derivative <br /> |
**[[4a6x]] – PfRadA ATPase domain (mutant) + ATP <br /> | **[[4a6x]] – PfRadA ATPase domain (mutant) + ATP <br /> | ||
**[[3ntu]], [[2gdj]] – MvRadA + AMPPNP <br /> | **[[3ntu]], [[2gdj]] – MvRadA + AMPPNP <br /> | ||
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**[[3fyh]], [[2f1j]], [[2fpk]] – MvRadA (mutant) + ADP <br /> | **[[3fyh]], [[2f1j]], [[2fpk]] – MvRadA (mutant) + ADP <br /> | ||
**[[3etl]], [[3ew9]], [[3ewa]] – MmRadA (mutant) + AMPPNP <br /> | **[[3etl]], [[3ew9]], [[3ewa]] – MmRadA (mutant) + AMPPNP <br /> | ||
| + | **[[5lkm]] - SpRadA + TDP<br /> | ||
*RadB recombinase | *RadB recombinase | ||
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**[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br /> | **[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br /> | ||
**[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br /> | **[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br /> | ||
| + | **[[5udo]] - INT coiled-coil domain - ''Listeria innocua''<br /> | ||
| + | **[[5frn]] - INT + DNA - human spumaretrovirus<br /> | ||
*Recombinase A (RecA) see [[Recombinase A]] | *Recombinase A (RecA) see [[Recombinase A]] | ||
Revision as of 18:20, 25 September 2017
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3D structures of resolvase
Updated on 25-September-2017
References
- ↑ West SC. The search for a human Holliday junction resolvase. Biochem Soc Trans. 2009 Jun;37(Pt 3):519-26. doi: 10.1042/BST0370519. PMID:19442245 doi:http://dx.doi.org/10.1042/BST0370519
- ↑ Haldenby S, White MF, Allers T. RecA family proteins in archaea: RadA and its cousins. Biochem Soc Trans. 2009 Feb;37(Pt 1):102-7. doi: 10.1042/BST0370102. PMID:19143611 doi:http://dx.doi.org/10.1042/BST0370102
- ↑ Dhar G, Sanders ER, Johnson RC. Architecture of the hin synaptic complex during recombination: the recombinase subunits translocate with the DNA strands. Cell. 2004 Oct 1;119(1):33-45. PMID:15454079 doi:http://dx.doi.org/10.1016/j.cell.2004.09.010
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
