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Resolvase

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<StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' >
<StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' >
== Function ==
== Function ==
Line 26: Line 25:
**[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br />
**[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br />
**[[4ep5]] – TtHJR RuvC (mutant)<br />
**[[4ep5]] – TtHJR RuvC (mutant)<br />
-
**[[1zp7]] – HJR RecU – ''Bacillus subtilis''<br />
+
**[[1zp7]] – BsHJR RecU – ''Bacillus subtilis''<br />
-
**[[1ob8]], [[1ob9]], [[1hh1]] – SsHJR – ''Sulfolobus solfataricus''<br />
+
**[[5fdk]] - BsHJR RecU (mutant) + DNA<br />
 +
**[[1ob8]], [[1ob9]], [[1hh1]], [[2eo0]] – SsHJR – ''Sulfolobus solfataricus''<br />
 +
**[[4tkd]], [[4tkk]] - SsHJR (mutant) - <br />
**[[2fco]] – HJR – ''Geobacillus kaustophilus''<br />
**[[2fco]] – HJR – ''Geobacillus kaustophilus''<br />
-
**[[1ipi]], [[1gef]] – HJR – ''Pyrococcus furiosus''<br />
+
**[[1ipi]], [[1gef]] – PfHJR – ''Pyrococcus furiosus''<br />
**[[1kcf]] – HJR – fission yeast<br />
**[[1kcf]] – HJR – fission yeast<br />
 +
**[[1bvs]] - RuvA - ''Mycobacterium leprae''<br />
 +
**[[5e6f]] - HJR - canarypox virus<br />
* Ser-recombinase
* Ser-recombinase
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**[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br />
**[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br />
**[[2gm5]] – EcGDR (mutant)<br />
**[[2gm5]] – EcGDR (mutant)<br />
-
**[[3guv]] – site-specific recombinase – ''Streptococcus pneumoniae''<br />
+
**[[3guv]] – Sp-site-specific recombinase – ''Streptococcus pneumoniae''<br />
-
**[[2r0q]] – S-rec+DNA – ''Staphylococcus aureus''<br />
+
**[[2r0q]] – SaS-rec+DNA – ''Staphylococcus aureus''<br />
 +
**[[3pkz]] - SaS-sin (mutant)<br />
**[[3lhf]] – SsS-rec<br />
**[[3lhf]] – SsS-rec<br />
Line 53: Line 57:
**[[2f1i]] – MvRec+AMPPNP<br />
**[[2f1i]] – MvRec+AMPPNP<br />
**[[2f1j]], [[2fpk]] - MvRec+ADP<br />
**[[2f1j]], [[2fpk]] - MvRec+ADP<br />
-
**[[1a0p]] – EcXerd Rec<br />
+
**[[1a0p]] – EcXerD Rec<br />
 +
**[[5dcf]] - EcXerD C-terminal/FTSK<br />
 +
**[[5hxy]] - XerD - ''Thermoplasma acidophilum''<br />
 +
**[[5jjv]], [[5jk0]] - XerH - ''Helicobacter pylori''<br />
* Cre recombinase
* Cre recombinase
Line 68: Line 75:
**[[4dc9]] – MvRadA C-terminal domain <br />
**[[4dc9]] – MvRadA C-terminal domain <br />
**[[2i1q]] – MvRadA (mutant) <br />
**[[2i1q]] – MvRadA (mutant) <br />
-
**[[1pzn]] – PfRadA <br />
+
**[[1pzn]], [[5fos]], [[5fot]], [[5fou]], [[5fox]], [[5fpk]], [[5fov]], [[5fow]] – PfRadA <br />
**[[4a6p]] – PfRadA ATPase domain (mutant) <br />
**[[4a6p]] – PfRadA ATPase domain (mutant) <br />
 +
**[[5lkq]] - SpRadA protease domain<br />
 +
**[[5j4l]], [[5jec]], [[5jed]], [[5jee]], [[5kdd]], [[5l8v]], [[5lb2]], [[5lb4]], [[5lbi]], [[5jfg]] - PfRadA (mutant)<br />
 +
**[[5h45]] - TtRadA C-terminal<br />
*RadA recombinase complex
*RadA recombinase complex
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**[[4b32]], [[4b33]] – PfRadA ATPase domain (mutant) + naphthol <br />
**[[4b32]], [[4b33]] – PfRadA ATPase domain (mutant) + naphthol <br />
**[[4b34]] – PfRadA ATPase domain (mutant) + aminobenzothiazole <br />
**[[4b34]] – PfRadA ATPase domain (mutant) + aminobenzothiazole <br />
-
**[[4b3c]], [[4b3d]] – PfRadA ATPase domain (mutant) + indole <br />
+
**[[4b3c]], [[4b3d]], [[5j4h]], [[5j4k]] – PfRadA ATPase domain (mutant) + indole derivative <br />
**[[4a6x]] – PfRadA ATPase domain (mutant) + ATP <br />
**[[4a6x]] – PfRadA ATPase domain (mutant) + ATP <br />
**[[3ntu]], [[2gdj]] – MvRadA + AMPPNP <br />
**[[3ntu]], [[2gdj]] – MvRadA + AMPPNP <br />
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**[[3fyh]], [[2f1j]], [[2fpk]] – MvRadA (mutant) + ADP <br />
**[[3fyh]], [[2f1j]], [[2fpk]] – MvRadA (mutant) + ADP <br />
**[[3etl]], [[3ew9]], [[3ewa]] – MmRadA (mutant) + AMPPNP <br />
**[[3etl]], [[3ew9]], [[3ewa]] – MmRadA (mutant) + AMPPNP <br />
 +
**[[5lkm]] - SpRadA + TDP<br />
*RadB recombinase
*RadB recombinase
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**[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br />
**[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br />
**[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br />
**[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br />
 +
**[[5udo]] - INT coiled-coil domain - ''Listeria innocua''<br />
 +
**[[5frn]] - INT + DNA - human spumaretrovirus<br />
*Recombinase A (RecA) see [[Recombinase A]]
*Recombinase A (RecA) see [[Recombinase A]]

Revision as of 18:20, 25 September 2017

Yeast Holliday junction resolvase dimer complex with sulfate, 1kcf

Drag the structure with the mouse to rotate

3D structures of resolvase

Updated on 25-September-2017

References

  1. ↑ West SC. The search for a human Holliday junction resolvase. Biochem Soc Trans. 2009 Jun;37(Pt 3):519-26. doi: 10.1042/BST0370519. PMID:19442245 doi:http://dx.doi.org/10.1042/BST0370519
  2. ↑ Haldenby S, White MF, Allers T. RecA family proteins in archaea: RadA and its cousins. Biochem Soc Trans. 2009 Feb;37(Pt 1):102-7. doi: 10.1042/BST0370102. PMID:19143611 doi:http://dx.doi.org/10.1042/BST0370102
  3. ↑ Dhar G, Sanders ER, Johnson RC. Architecture of the hin synaptic complex during recombination: the recombinase subunits translocate with the DNA strands. Cell. 2004 Oct 1;119(1):33-45. PMID:15454079 doi:http://dx.doi.org/10.1016/j.cell.2004.09.010

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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