NADH-quinone oxidoreductase

From Proteopedia

Revision as of 21:47, 11 January 2017

spinqualitylabelsall models NADH-quinone oxidoreductase chains 1 (grey), 2 (green), 3 (pink), 4 (yellow), 5 (magenta), 6 (cyan), 9 (gold), 15 (red) + Fe4S4 + Fe2S2 + FMN (PDB ode 3i9v). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function NADH-quinone oxidoreductase (NQO) (Complex I) pumps protons across the membrane of mitochondria or plasma in bacteria. NQO contains 14 central subunits and up to 32 accessory subunits. NQO contains FMN and 8 to 9 iron-sulfur clusters. Seven of the iron-sulfur clusters form a linear electron transfer chain between the FMN and quinone[1]. For more details see NADH:ubiquinone oxidoreductase NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol.

3D Structures of NADH-quinone oxidoreductase

Updated on 11-January-2017

2fug – TtNQO chains 1,2,3,4,5,6,9 + conserved protein + Fe4S4 + Fe2S2 + FMN – Thermus thermophilus
3i9v – TtNQO chains 1,2,3,4,5,6,9,15 + Fe4S4 + Fe2S2 + FMN
3iam – TtNQO chains 1,2,3,4,5,6,9,15 + Fe4S4 + Fe2S2 + FMN + NADH
3ias – TtNQO chains 1,2,3,4,5,6,9,15 + Fe4S4 + Fe2S2 + FMN
3m9s – TtNQO chains 1,2,3,4,7,8,10,11,12,13,14,15,B,C,I,15 + Fe4S4 + Fe2S2 + FMN
4he8 – TtNQO chains 7,8,10,11,12,13,14 membrane domain
2ybb – TtNQO chains 1,2,3,4,5,6,9,15,M,N,K + cytochrome B,C1 + cytochrome C oxidase + Fe4S4 + Fe2S2 + FMN – Cryo-EM
3m9c, 3rko – NQO subunits NUOA,J,K,L,M,N membrane domain – Escherichia coli

References

1. ↑ Brandt U. Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem. 2006;75:69-92. PMID:16756485 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142539