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Virus protease
From Proteopedia
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| - | + | {{STRUCTURE_1odw| PDB=1odw | SIZE=350| SCENE=Virus_protease/Cv/1 |right|CAPTION=HIV-1 protease dimer complex with tert-butylcarbonate [[1odw]] }} | |
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'''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | '''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | ||
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. | HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. | ||
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*[[Molecular Playground/Dengue Virus Protease]] | *[[Molecular Playground/Dengue Virus Protease]] | ||
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== 3D Structures of Virus proteases == | == 3D Structures of Virus proteases == | ||
Revision as of 11:41, 21 July 2017
Virus proteases include HIV protease, XMRV protease, retropepsin.
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.
See also
- Immunodeficiency virus protease
- Human Immunodeficiency Virus
- HIV-1 protease
- HIV Protease Inhibitor Pharmacokinetics
- HIV Protease Inhibitor Resistance Profile
- HIV Protease Resistance
- Molecular Playground/Dengue Virus Protease
- Viability of a drug-resistant HIV-1 protease mutant
- Molecular Playground/Dengue Virus Protease
3D Structures of Virus proteases
Updated on 21-July-2017
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
