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Ribosomal protein S2
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' caption='Ribosomal protein S2 (RPS2), (PDB code [[3kc4]])' > | |
== Function == | == Function == | ||
| - | [[Ribosomal protein S2]] (RPS2) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S2/Cv/ | + | [[Ribosomal protein S2]] (RPS2) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S2/Cv/1'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. Its N-terminal is rich in Arg-Gly repeats and has two RGGF copies which are believed to be associated with nuclear localization and binding to RNA. In archaea the protein is called S2P (RPS2P). |
== Relevance == | == Relevance == | ||
RPS2 is a tumor antigen recognized by antibodies. Thus its peptide can be suitable for use in immunotherapy for HLA-A26+ cancer patients<ref>PMID:12694581</ref>. RPS2 is over expressed in liver cancer<ref>PMID:12422231</ref>. | RPS2 is a tumor antigen recognized by antibodies. Thus its peptide can be suitable for use in immunotherapy for HLA-A26+ cancer patients<ref>PMID:12694581</ref>. RPS2 is over expressed in liver cancer<ref>PMID:12422231</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of Ribosomal protein S2 == | == 3D Structures of Ribosomal protein S2 == | ||
Revision as of 07:43, 29 September 2017
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3D Structures of Ribosomal protein S2
Updated on 29-September-2017
1vi5, 1vi6 – RPS2P – Archaeoglobus fulgidus
1x18 – RPS2 + RPS7 + RPS11 + RPS18 + GTP-binding protein + RNA – Thermus thermophilus – Cryo EM
4toi – RPS2/RPS1 N-terminal – Escherichia coli
References
- ↑ Koga M, Shichijo S, Yamada A, Ashihara J, Sawamizu H, Kusukawa J, Itoh K. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. Tissue Antigens. 2003 Feb;61(2):136-45. PMID:12694581
- ↑ Kowalczyk P, Woszczynski M, Ostrowski J. Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro. Acta Biochim Pol. 2002;49(3):615-24. PMID:12422231 doi:http://dx.doi.org/024903615
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