RING box protein

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Revision as of 10:08, 25 October 2017

spinqualitylabelsall models Human RING finger protein 1 (green) complex with cullin-1 (grey), glomulin (magenta) and Zn+2 ions (grey) (PDB code 4f52) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex[1]. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction. Relevance Overexpression of RBX1 contributes to tumor progression and poor prognosis of non-muscle-invasive bladder transitional cell carcinoma[2]. RBX1 and RBX2 are overexpressed in multiple human cancer tissues and required for the growth and survival of cancer cells[3].

3D Structures of RING box protein

Updated on 25-October-2017

References

1. ↑ Jia L, Bickel JS, Wu J, Morgan MA, Li H, Yang J, Yu X, Chan RC, Sun Y. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem. 2011 Feb 4;286(5):3379-86. doi: 10.1074/jbc.M110.188425. Epub 2010, Nov 29. PMID:21115485 doi:http://dx.doi.org/10.1074/jbc.M110.188425
2. ↑ Wang W, Qiu J, Liu Z, Zeng Y, Fan J, Liu Y, Guo Y. Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. J Surg Oncol. 2013 Jun;107(7):758-61. doi: 10.1002/jso.23317. Epub 2013 Apr 23. PMID:23609182 doi:http://dx.doi.org/10.1002/jso.23317
3. ↑ Wei D, Sun Y. Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets. Genes Cancer. 2010 Jul;1(7):700-7. doi: 10.1177/1947601910382776. PMID:21103004 doi:http://dx.doi.org/10.1177/1947601910382776