Aminotransferase

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Line 70: Line 70:
**[[2eh6]] – ACOAT + PLP – ''Aquifex aeolicus'' <br />
**[[2eh6]] – ACOAT + PLP – ''Aquifex aeolicus'' <br />
**[[3nx3]] – CjACOAT – ''Campylobacter jejuni'' <br />
**[[3nx3]] – CjACOAT – ''Campylobacter jejuni'' <br />
 +
**[[5viu]] – ACOAT – ''Elizabethkingia anophelis'' <br />
 +
**[[4jev]] – StACOAT + PLP derivative – ''Salmonella typhimurium'' <br />
 +
**[[4jey]] – StACOAT (mutant) + PLP <br />
 +
**[[4jf0]], [[4f01]] – StACOAT (mutant) + PLP derivative<br />
 +
**[[4jew]], [[4jex]], [[4jez]] – StACOAT (mutant) + canaline <br />
*Succinylornithine aminotransferase
*Succinylornithine aminotransferase
Line 83: Line 88:
*Alanine glyoxylate aminotransferase
*Alanine glyoxylate aminotransferase
-
**[[1h0c]], [[2yob]], [[5f9s]] – hAGA + PLP <br />
+
**[[1h0c]], [[2yob]], [[5f9s]], [[5og0]] – hAGA + PLP <br />
-
**[[4cbr]], [[4cbs]] – hAGA (mutant) + PLP <br />
+
**[[4cbr]], [[4cbs]], [[5ofy]], [[5luc]] – hAGA (mutant) + PLP <br />
**[[1j04]], [[5hhy]] – hAGA + PLP derivative <br />
**[[1j04]], [[5hhy]] – hAGA + PLP derivative <br />
**[[4i8a]] – hAGA (mutant) + PLP derivative <br />
**[[4i8a]] – hAGA (mutant) + PLP derivative <br />
Line 108: Line 113:
**[[1ekf]], [[1ekp]], [[1ekv]] – hBCAT + PLP <br />
**[[1ekf]], [[1ekp]], [[1ekv]] – hBCAT + PLP <br />
 +
**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]], [[5mpr]] – hBCAT (mutant) + PLP <br />
**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />
**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />
**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />
**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />
**[[5i60]], [[5i5y]], [[5i5x]], [[5i5w]], [[5i5v]], [[5i5u]], [[5i5t]], [[5i5s]], [[5hne]] – hBCAT + PLP + biaryl amide<br />
**[[5i60]], [[5i5y]], [[5i5x]], [[5i5w]], [[5i5v]], [[5i5u]], [[5i5t]], [[5i5s]], [[5hne]] – hBCAT + PLP + biaryl amide<br />
-
**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]] – hBCAT (mutant) + PLP <br />
 
**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />
**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />
**[[4chi]] – AfBCAT + PLP – ''Aspergillus fumigatus'' <br />
**[[4chi]] – AfBCAT + PLP – ''Aspergillus fumigatus'' <br />
Line 119: Line 124:
**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />
**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
 +
**[[5u3f]] – MtBCAT + cycloserine <br />
*Aromatic amino acid aminotransferase
*Aromatic amino acid aminotransferase
Line 180: Line 186:
**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />
**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />
**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />
**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />
-
**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]] – GABA + inactivator - pig <br />
+
**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]], [[6b6g]] – GABA + inactivator - pig <br />
*ArnB aminotransferase
*ArnB aminotransferase
-
**[[1mdo]] - StArnB + PLP derivative – ''Salmonella typhimurium''<br />
+
**[[1mdo]] - StArnB + PLP derivative <br />
**[[1mdx]] – StArnB + PLP + oxoglutarate<br />
**[[1mdx]] – StArnB + PLP + oxoglutarate<br />
**[[1mdz]] – StArnB + PLP + PLP derivative<br />
**[[1mdz]] – StArnB + PLP + PLP derivative<br />
Line 208: Line 214:
*Alpha-aminoadipate aminotransferase
*Alpha-aminoadipate aminotransferase
-
**[[2egy]], [[5eun]] - TtLysN + PLP <br />
+
**[[2egy]], [[5eun]] - TtAADAT + PLP <br />
-
**[[3cbf]], [[2zyj]] - TtLysN + PLP derivative<br />
+
**[[3cbf]], [[2zyj]] - TtAADAT + PLP derivative<br />
-
**[[2zp7]], [[2z1y]] - TtLysN + PLP + leucine<br />
+
**[[2zp7]], [[2z1y]] - TtAADAT + PLP + leucine<br />
-
**[[5tf5]] - hLysN + PLP derivative + inhibitor<br />
+
**[[4je5]] - AADAT + PLP derivative + PLP - yeast<br />
-
**[[5efs]] - hLysN II <br />
+
*Broad specificity aminotransferase
*Broad specificity aminotransferase
Line 220: Line 225:
*Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
*Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
-
**[[4w1x]], [[4w1w]], [[4w1v]], [[4xjl]], [[4xjm]], [[4xjo]], [[4xjp]] - MtDAPA + PLP + inhibitor<br />
+
**[[4w1x]], [[4w1w]], [[4w1v]], [[4xjl]], [[4xjm]], [[4xjo]], [[4xjp]], [[4wya]], [[4wyc]], [[4wyd]], [[4wye]], [[4wyf]], [[4wyg]], [[4xew]] - MtDAPA + PLP + inhibitor<br />
**[[4mqr]], [[4mqq]], [[4mqp]] - MtDAPA + inhibitor<br />
**[[4mqr]], [[4mqq]], [[4mqp]] - MtDAPA + inhibitor<br />
**[[5uc7]] - DAPA + PLP derivative – ''Citrobacter rodentium''<br />
**[[5uc7]] - DAPA + PLP derivative – ''Citrobacter rodentium''<br />
 +
**[[5te2]] - MbDAPA + inhibitor – ''Mycobacterium bovis''<br />
 +
**[[5kgs]], [[5kgt]] - MbDAPA + PLP + inhibitor<br />
*Putrescine aminotransferase
*Putrescine aminotransferase
Line 232: Line 239:
**[[4uho]], [[4uhn]], [[4uhm]] - PaOAAT + PLP <br />
**[[4uho]], [[4uhn]], [[4uhm]] - PaOAAT + PLP <br />
 +
 +
*C-6’ aminotransferase
 +
 +
**[[6cbo]] - AT – ''Micromonospora echinospora'' <br />
 +
 +
*Kynurenine aminotransferase
 +
 +
**[[5veh]] – AaKAT + PLP derivative <br />
 +
**[[5vep]], [[5veq]], [[5ver]] – mKAT 3 + PLP derivative <br />
 +
**[[4wlh]], [[4wlj]] – hKAT 1 + PLP derivative <br />
 +
**[[5efs]] – hKAT 2 <br />
 +
**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />
 +
 +
*Aminotransferase class III
 +
 +
**[[5ghg]], [[5ghf]] – AT3 + PLP derivative – ''Orchrobactrum anthropi''<br />
 +
**[[5m46]] – RfAT3 + PLP – ''Rhizobium freirei''<br />
 +
**[[5m49]] – RfAT3 + PLP + azepan derivative<br />
 +
**[[5m4b]], [[5m4d]] – RfAT3 (mutant) + azepan derivative<br />
 +
**[[5d95]] – AT3 + PLP derivative – ''Sphaerobacter thermophilus''<br />
 +
 +
*Aminotransferase class IV
 +
 +
**[[4tvi]] – AT4 + PLP derivative – ''Brucella abortus''<br />
 +
}}
}}

Revision as of 11:07, 13 March 2018

E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code 1gew)

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3D structures of aminotransferase

Updated on 13-March-2018

References

  1. ↑ Mizuguchi H, Hayashi H, Miyahara I, Hirotsu K, Kagamiyama H. Characterization of histidinol phosphate aminotransferase from Escherichia coli. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):321-4. PMID:12686152
  2. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  3. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  4. ↑ Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, Kagamiyama H. Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Biochemistry. 2001 Apr 17;40(15):4633-44. PMID:11294630

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