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Molecular Playground/Insulin
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(Difference between revisions)
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** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[5cny]], [[5bts]], [[5bqq]], [[5bpo]], [[5boq]] - hIns A chain + B chain – human <BR /> | ** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[5cny]], [[5bts]], [[5bqq]], [[5bpo]], [[5boq]] - hIns A chain + B chain – human <BR /> | ||
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR /> | ** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR /> | ||
| - | ** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[5hrq]], [[5hqi]], [[5hpu]], [[5hpr]], [[5ena]], [[5en9]] | + | ** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[5hrq]], [[5hqi]], [[5hpu]], [[5hpr]], [[5ena]], [[5en9]], [[6ck2]], [[5uu4]], [[5uu3]], [[5uu2]], [[5usv]], [[5uss]], [[5usp]], [[5uru]], [[5urt]], [[5uqa]], [[5uoz]], [[1w8p]], [[4cxl]], [[4cxn]], [[4cy7]], [[4nib]], [[4une]], [[4ung]], [[4unh]], [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]],[[ 2ws7]], [[1qj0]], [[3p2x]] – hIns A chain + B chain (mutant) <BR /> |
| - | + | ||
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR /> | ** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR /> | ||
| - | ** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx | + | ** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]], [[5t7r]], [[1zeh]], [[3zi3]], [[5azz]] - hIns A chain (mutant) + B chain <BR /> |
| - | + | **[[5mwq]] - hIns A chain (mutant) + B chain (mutant)<br /> | |
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<BR /> | ** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<BR /> | ||
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR /> | ** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR /> | ||
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** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]], [[2mpg]], [[2mvc]] - hIns A chain + B chain – NMR<BR /> | ** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]], [[2mpg]], [[2mvc]] - hIns A chain + B chain – NMR<BR /> | ||
** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR /> | ** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR /> | ||
| - | ** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]], [[2mpi]], [[2l1y]], [[2l1z]] - hIns A chain (mutant) + B chain – NMR<BR /> | + | ** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]], [[2mpi]], [[2l1y]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<BR /> |
** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<BR /> | ** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<BR /> | ||
** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR /> | ** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR /> | ||
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** [[2jzq]] - hIns A chain – NMR<BR /> | ** [[2jzq]] - hIns A chain – NMR<BR /> | ||
** [[1ho0]] - hIns B chain (mutant) – NMR<BR /> | ** [[1ho0]] - hIns B chain (mutant) – NMR<BR /> | ||
| - | ** [[2lwz]] – hIns single chain - NMR<br /> | + | ** [[2lwz]], [[5bwt]] – hIns single chain - NMR<br /> |
**[[5miz]] - bIns A chain + B chain – NMR | **[[5miz]] - bIns A chain + B chain – NMR | ||
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** [[3q6e]] - hIns A chain + B chain + synthetic receptor<BR /> | ** [[3q6e]] - hIns A chain + B chain + synthetic receptor<BR /> | ||
** [[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme<br /> | ** [[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme<br /> | ||
| - | ** [[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant)<br /> | + | ** [[2wby]], [[2wc0]], [[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme (mutant)<br /> |
| - | ** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br /> | + | ** [[3w11]], [[5kqv]], [[3w14]], [[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br /> |
| + | **[[6ce7]], [[6ce9]], [[6ceb]] - hIns A chain + B chain + insulin receptor <br /> | ||
**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br /> | **[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br /> | ||
**[[5mam]] - hIns A chain + B chain + serotonin <br /> | **[[5mam]] - hIns A chain + B chain + serotonin <br /> | ||
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** [[1zei]] - pIns A chain (mutant) + cresol<br /> | ** [[1zei]] - pIns A chain (mutant) + cresol<br /> | ||
** [[7ins]] - pIns A chain + B chain + clupeine + cresol<br /> | ** [[7ins]] - pIns A chain + B chain + clupeine + cresol<br /> | ||
| - | ** [[5kqv]] - bIns A chain + B chain + insulin-degrading enzyme + antibody<br /> | ||
* Proinsulin | * Proinsulin | ||
Revision as of 07:57, 22 July 2018
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.
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Insulin Structure & Function
Diabetes & Hypoglycemia
Insulin (Hebrew)
Insulin mo-or-sl (Hebrew).
3D structures of Insulin
(Updated on 22-July-2018)
References
- ↑ Sonksen P, Sonksen J. Insulin: understanding its action in health and disease. Br J Anaesth. 2000 Jul;85(1):69-79. PMID:10927996
- ↑ Davidson HW. (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys. 2004;40(3 Suppl):143-58. PMID:15289650
- ↑ Zakova L, Barth T, Jiracek J, Barthova J, Zorad S. Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain. Biochemistry. 2004 Mar 2;43(8):2323-31. PMID:14979729 doi:http://dx.doi.org/10.1021/bi036001w
Additional Resources
For additional information, see: Diabetes & Hypoglycemia
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Shelly Livne, Karsten Theis, David Canner, Whitney Stoppel, Alexander Berchansky, Yael Shwartz, Lynmarie K Thompson, Jaime Prilusky
