GTPase KRas
From Proteopedia
(Difference between revisions)
| Line 15: | Line 15: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The GDP-bound KRas binds a <scene name='78/781207/Cv/2'>small molecule inhibitor in its binding cleft</scene> following conformational change of the protein<ref>PMID:22566140</ref>. | + | The GDP-bound KRas binds a <scene name='78/781207/Cv/2'>small molecule inhibitor in its binding cleft</scene> following conformational change of the protein<ref>PMID:22566140</ref>. |
| + | *<scene name='78/781207/Cv/9'>Inhibitor binding cleft</scene>. | ||
*<scene name='78/781207/Cv/7'>GDP binding site</scene>. | *<scene name='78/781207/Cv/7'>GDP binding site</scene>. | ||
*<scene name='78/781207/Cv/8'>Mg coordination site</scene>. | *<scene name='78/781207/Cv/8'>Mg coordination site</scene>. | ||
| + | *<scene name='78/781207/Cv/10'>GDP/Mg binding cleft</scene>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of GTPase KRas == | == 3D Structures of GTPase KRas == | ||
Revision as of 13:29, 25 February 2018
| |||||||||||
3D Structures of GTPase KRas
Updated on 25-February-2018
References
- ↑ Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science. 1990 Feb 23;247(4945):939-45. PMID:2406906
- ↑ Shibata H, Ohike N, Norose T, Isobe T, Suzuki R, Imai H, Shiokawa A, Aoki T, Murakami M, Mizukami H, Tanaka JI, Takimoto M. Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178. PMID:29187496 doi:http://dx.doi.org/10.21873/anticanres.12178
- ↑ Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012 May 8. doi: 10.1002/anie.201201358. PMID:22566140 doi:10.1002/anie.201201358
