GTPase KRas

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Line 40: Line 40:
**[[5kyk]] – hKRas + inhibitor <br />
**[[5kyk]] – hKRas + inhibitor <br />
**[[4nmm]] – hKRas (mutant) + inhibitor <br />
**[[4nmm]] – hKRas (mutant) + inhibitor <br />
-
**[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]] – hKRas (mutant) + GDP + inhibitor <br />
+
**[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q01]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]], [[6b0v]], [[6b0y]], [[5yxz]], [[5yy1]], [[4pzy]], [[4pzz]] – hKRas (mutant) + GDP + inhibitor <br />
**[[5vbz]] – hKRas (mutant) + GNP + inhibitor <br />
**[[5vbz]] – hKRas (mutant) + GNP + inhibitor <br />
**[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br />
**[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br />
Line 49: Line 49:
**[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br />
**[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br />
**[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br />
**[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br />
-
**[[5o2s]], [[5tb5]] – hKRas + GMP-PDE d + farnesyl + GDP <br />
+
**[[5tb5]], [[5tar]] – hKRas + GMP-PDE d + farnesyl + GDP <br />
**[[5o2t]], [[5mla]] – hKRas + darpin 55 + GSP <br />
**[[5o2t]], [[5mla]] – hKRas + darpin 55 + GSP <br />
-
**[[5o2s]] – hKRas + R11.1.6 + GNP <br />
+
**[[5ufe]] – hKRas + R11.1.6 + GNP <br />
**[[5ufq]] – hKRas (mutant) + R11.1.6 + GNP <br />
**[[5ufq]] – hKRas (mutant) + R11.1.6 + GNP <br />
**[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br />
**[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br />

Revision as of 09:58, 7 June 2018

Structure of human GDP-bound GTPase KRas G12 mutant complex with inhibitor and GDP (PDB entry 4ept)

Drag the structure with the mouse to rotate

3D Structures of GTPase KRas

Updated on 07-June-2018

References

  1. ↑ Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science. 1990 Feb 23;247(4945):939-45. PMID:2406906
  2. ↑ Shibata H, Ohike N, Norose T, Isobe T, Suzuki R, Imai H, Shiokawa A, Aoki T, Murakami M, Mizukami H, Tanaka JI, Takimoto M. Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178. PMID:29187496 doi:http://dx.doi.org/10.21873/anticanres.12178
  3. ↑ Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012 May 8. doi: 10.1002/anie.201201358. PMID:22566140 doi:10.1002/anie.201201358

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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