Sandbox Reserved 1416
From Proteopedia
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==Organism or Origin== | ==Organism or Origin== | ||
1aoi, or the complex between nucleosome core particle (H3,h4,h2a,h2b) and 146 BP long DNA fragment, was originally found in the African clawed frog (Xenopus laevis). | 1aoi, or the complex between nucleosome core particle (H3,h4,h2a,h2b) and 146 BP long DNA fragment, was originally found in the African clawed frog (Xenopus laevis). | ||
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== Protein Structure == | == Protein Structure == | ||
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== Function == | == Function == | ||
| - | The function of this protein complex is to package DNA | + | The function of this protein complex is to package DNA into compact nucleosomes. The phosphate backbone of DNA is negatively charged, which allows it to bind tightly to the positively charged histone. |
== Significance == | == Significance == | ||
| - | This histone complex is | + | This histone complex allows for the storage and retrieval of genetic material. While DNA is 'stored' in the nucleosome, it is inaccessible to transcription factors and other non-histone proteins. As a result, it plays a major role in transcription control. Additionally, this protein is found in a common testing organism, the African Clawed frog. |
Revision as of 19:30, 25 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Contents |
1aoi
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Organism or Origin
1aoi, or the complex between nucleosome core particle (H3,h4,h2a,h2b) and 146 BP long DNA fragment, was originally found in the African clawed frog (Xenopus laevis).
Protein Structure
The histone complex is 418 amino acids long, and is made up of four pairs of polypeptides: , , , and . Alpha of all four core histones generate a positive charge, essential to the function of the protein.
Function
The function of this protein complex is to package DNA into compact nucleosomes. The phosphate backbone of DNA is negatively charged, which allows it to bind tightly to the positively charged histone.
Significance
This histone complex allows for the storage and retrieval of genetic material. While DNA is 'stored' in the nucleosome, it is inaccessible to transcription factors and other non-histone proteins. As a result, it plays a major role in transcription control. Additionally, this protein is found in a common testing organism, the African Clawed frog.
