Fatty acid synthase

(Difference between revisions)

Revision as of 11:02, 17 March 2019

Human FAS thioesterase domain complex with fatty acid (PDB code 3tjm)

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Updated on 17-March-2019

↑ Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003 Jul;42(4):289-317. PMID:12689621
↑ Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. Epub 2011 Sep 9. PMID:21908709 doi:10.1073/pnas.1112334108

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 == Structural insights ==
-<scene name='48/484817/Cv/3'>Active site predominantly consists of hydrophobic/non-polar residues</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). The <scene name='48/484817/Cv/5'>long fatty acid ligand is nestled in a long groove and tunnel</scene><ref>PMID:21908709</ref>.
+<scene name='48/484817/Cv/6'>Active site predominantly consists of hydrophobic/non-polar residues</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). The <scene name='48/484817/Cv/7'>long fatty acid ligand is nestled in a long groove and tunnel</scene><ref>PMID:21908709</ref>.
 </StructureSection>