5ls8
From Proteopedia
(Difference between revisions)
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==Light-activated ruthenium complex bound to a DNA quadruplex== | ==Light-activated ruthenium complex bound to a DNA quadruplex== | ||
| - | <StructureSection load='5ls8' size='340' side='right' caption='[[5ls8]], [[Resolution|resolution]] 1.78Å' scene=''> | + | <StructureSection load='5ls8' size='340' side='right'caption='[[5ls8]], [[Resolution|resolution]] 1.78Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ls8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LS8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5ls8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LS8 FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ls8 OCA], [http://pdbe.org/5ls8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ls8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ls8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ls8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ls8 OCA], [http://pdbe.org/5ls8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ls8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ls8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ls8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The new complexes [Ru(TAP)2 (11-CN-dppz)](2+) , [Ru(TAP)2 (11-Br-dppz)](2+) and [Ru(TAP)2 (11,12-diCN-dppz)](2+) are reported. The addition of nitrile substituents to the dppz ligand of the DNA photo-oxidising complex [Ru(TAP)2 (dppz)](2+) promote pi-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of Lambda-[Ru(TAP)2 (11-CN-dppz)](2+) with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at the terminus. The structure obtained is compared to that formed with the 11-Br and 11,12-dinitrile derivatives, highlighting the stabilization of syn guanine by this enantiomer when the terminal base pair is GC. In contrast the AT base pair has the normal Watson-Crick orientation, highlighting the difference in charge distribution between the two purine bases and the complementarity of the dppz-purine interaction. The asymmetry of the cavity highlights the importance of the purine-dppz-purine stacking interaction. | ||
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| + | X-ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru-dppz Complexes.,McQuaid K, Hall JP, Brazier JA, Cardin DJ, Cardin CJ Chemistry. 2018 Oct 22;24(59):15859-15867. doi: 10.1002/chem.201803021. Epub 2018, Oct 1. PMID:30063271<ref>PMID:30063271</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ls8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abell, H]] | [[Category: Abell, H]] | ||
[[Category: Cardin, C J]] | [[Category: Cardin, C J]] | ||
Revision as of 15:47, 28 August 2019
Light-activated ruthenium complex bound to a DNA quadruplex
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