6eok
From Proteopedia
(Difference between revisions)
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<StructureSection load='6eok' size='340' side='right' caption='[[6eok]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='6eok' size='340' side='right' caption='[[6eok]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6eok]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EOK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6eok]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EOK FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eca|3eca]], [[1nns|1nns]], [[1jaz|1jaz]], [[1ihd|1ihd]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eca|3eca]], [[1nns|1nns]], [[1jaz|1jaz]], [[1ihd|1ihd]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ansB, b2957, JW2924 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eok OCA], [http://pdbe.org/6eok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eok RCSB], [http://www.ebi.ac.uk/pdbsum/6eok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eok ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eok OCA], [http://pdbe.org/6eok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eok RCSB], [http://www.ebi.ac.uk/pdbsum/6eok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eok ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Resonance assignment and structural characterization of pharmacologically-relevant proteins promises to improve their understanding and safety by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to "evade" the standard structural biology methodologies. We here demonstrate that it is possible to obtain the resonance assignment and a reliable structural model of large PEGylated proteins through an integrated approach encompassing NMR and X-ray crystallography. | ||
| + | |||
| + | Characterization of PEGylated asparaginase: new opportunities from NMR analysis of large pegylated therapeutics.,Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C Chemistry. 2018 Nov 21. doi: 10.1002/chem.201804488. PMID:30462348<ref>PMID:30462348</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6eok" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Asparaginase]] | [[Category: Asparaginase]] | ||
| + | [[Category: Ecoli]] | ||
[[Category: Calderone, V]] | [[Category: Calderone, V]] | ||
[[Category: Carlon, A]] | [[Category: Carlon, A]] | ||
Revision as of 07:04, 5 December 2018
Crystal structure of E. coli L-asparaginase II
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Categories: Asparaginase | Ecoli | Calderone, V | Carlon, A | Cerofolini, L | Fragai, M | Giuntini, S | Luchinat, C | Parigi, G | Ravera, E | Hydrolase | L-asparaginase ii
