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3bfx
From Proteopedia
(Difference between revisions)
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==Crystal structure of human sulfotransferase SULT1C1 in complex with PAP== | ==Crystal structure of human sulfotransferase SULT1C1 in complex with PAP== | ||
| - | <StructureSection load='3bfx' size='340' side='right' caption='[[3bfx]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3bfx' size='340' side='right'caption='[[3bfx]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3bfx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3bfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2etg 2etg] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhe 1zhe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BFX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1C2, SULT1C1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1C2, SULT1C1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfx OCA], [https://pdbe.org/3bfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bfx RCSB], [https://www.ebi.ac.uk/pdbsum/3bfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bfx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ST1C2_HUMAN ST1C2_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bochkarev, A]] | [[Category: Bochkarev, A]] | ||
Revision as of 18:57, 20 October 2021
Crystal structure of human sulfotransferase SULT1C1 in complex with PAP
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Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Dombrovski, L | Dong, A | Edwards, A M | Loppnau, P | Plotnikov, A N | Structural genomic | Sundstrom, M | Weigelt, J | Alternative splicing | Cytoplasm | Pap | Polymorphism | PSI, Protein structure initiative | Sgc | Sulfotransferase | Transferase
