Flagellar protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
<StructureSection load='1io1' size='340' side='right' caption='Flagellin major fragment of ''Salmonella typhimurium'' (PDB code [[1io1]])' scene=''>
<StructureSection load='1io1' size='340' side='right' caption='Flagellin major fragment of ''Salmonella typhimurium'' (PDB code [[1io1]])' scene=''>
 +
__TOC__
 +
 +
==Function==
 +
[[Image:Flagellum1 800px.jpg|left|thumb|The bacterial flagellum consists of a filament, a universal joint (hook), and a motor (basal body).|200px]]<br />
[[Image:Flagellum1 800px.jpg|left|thumb|The bacterial flagellum consists of a filament, a universal joint (hook), and a motor (basal body).|200px]]<br />
Flagella (singular: flagellum) enable bacteria to swim towards sources of nutrition, and away from sources of toxins. Such directed motility is termed ''[http://en.wikipedia.org/wiki/Chemotaxis chemotaxis]''. Rapid swimming helps [http://en.wikipedia.org/wiki/Bdellovibrio Bdellovibrio] penetrate and parasitize their host bacteria, but flagella are not always essential for virulence<ref name="virulence1">PMID: 2152887</ref>. Flagella are important in responses to quorum sensing<ref name="quorum1">PMID: 15449604</ref> and biofilm formation<ref name="biofilms1">PMID: 19231189</ref><ref name="biofilms2">PMID: 17416647</ref>. Flagella may also be involved in functions other than motility<ref name="otherfunctions">PMID: 17920274</ref>.
Flagella (singular: flagellum) enable bacteria to swim towards sources of nutrition, and away from sources of toxins. Such directed motility is termed ''[http://en.wikipedia.org/wiki/Chemotaxis chemotaxis]''. Rapid swimming helps [http://en.wikipedia.org/wiki/Bdellovibrio Bdellovibrio] penetrate and parasitize their host bacteria, but flagella are not always essential for virulence<ref name="virulence1">PMID: 2152887</ref>. Flagella are important in responses to quorum sensing<ref name="quorum1">PMID: 15449604</ref> and biofilm formation<ref name="biofilms1">PMID: 19231189</ref><ref name="biofilms2">PMID: 17416647</ref>. Flagella may also be involved in functions other than motility<ref name="otherfunctions">PMID: 17920274</ref>.
Line 40: Line 44:
During assembly of the flagellum, its protein components are transported through hollow cores of the basal body, hook and filament, assembling at the end of the nascent flagellum<ref name="assembly1">PMID: 18931786</ref>. The [http://www.fbs.osaka-u.ac.jp/eng/labo/09a.html Namba Group] has prepared a [http://www.fbs.osaka-u.ac.jp/labs/namba/npn/movie5.html movie illustrating their understanding of the assembly process as of about 2004].
During assembly of the flagellum, its protein components are transported through hollow cores of the basal body, hook and filament, assembling at the end of the nascent flagellum<ref name="assembly1">PMID: 18931786</ref>. The [http://www.fbs.osaka-u.ac.jp/eng/labo/09a.html Namba Group] has prepared a [http://www.fbs.osaka-u.ac.jp/labs/namba/npn/movie5.html movie illustrating their understanding of the assembly process as of about 2004].
{{Clear}}
{{Clear}}
 +
 +
==3D structures of flagellar protein==
 +
[[Flagellar protein 3D structures]]
 +
</StructureSection>
</StructureSection>
Line 45: Line 53:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*Flagellar protein FlaG
 +
 +
**[[5tuh]] – SaFlaG – ''Sulfolobus acidocaldarius''<br />
 +
**[[5tug]] – SaFlaG + FlaF<br />
*Flagellar protein FlgA
*Flagellar protein FlgA
**[[3vki]], [[3vjp]], [[3tee]] – StFlgA – ''Salmonella typhimurium''<br />
**[[3vki]], [[3vjp]], [[3tee]] – StFlgA – ''Salmonella typhimurium''<br />
-
**[[3frn]] – FlgA – ''Thermotoga maritima''<br />
+
**[[3frn]] – TmFlgA – ''Thermotoga maritima''<br />
**[[6ch3]] – StFlgA + flagellin<br />
**[[6ch3]] – StFlgA + flagellin<br />
 +
 +
*Flagellar protein FlgD
 +
 +
**[[4zzf]] – HpFlgD – ''Helicobacter pylori'' <br />
 +
**[[3osv]] – PaFlgD residues 100-237 – ''Pseudomonas aeruginosa''<br />
 +
**[[3c12]] – XcFlgD – ''Xanthomonas campestris''<br />
*Flagellar protein FlgE
*Flagellar protein FlgE
**[[5xbj]], [[5az4]] – CjFlgE – ''Campylobacter jejuni''<br />
**[[5xbj]], [[5az4]] – CjFlgE – ''Campylobacter jejuni''<br />
 +
**[[5jxl]] – CjFlgE – Cryo EM<br />
**[[5ay6]] – FlgE – ''Caulobacter crescntus''<br />
**[[5ay6]] – FlgE – ''Caulobacter crescntus''<br />
**[[3a69]] – SeFlgE – ''Salmonella enterica'' – Cryo EM<br />
**[[3a69]] – SeFlgE – ''Salmonella enterica'' – Cryo EM<br />
Line 60: Line 80:
**[[1wlg]] – StFlgE <br />
**[[1wlg]] – StFlgE <br />
-
*Flagellar protein FlgK
+
*Flagellar protein FlgG or flagellar basal-body rod protein
 +
 
 +
**[[5wrh]] – StFlgG – Cryo EM <br />
 +
 
 +
*Flagellar protein FlgJ
 +
 
 +
**[[4qdn]] – TmFlgJ <br />
 +
 
 +
*Flagellar protein FlgK or flagellar hook-associated protein 1
**[[5xbj]] – CjFlgK <br />
**[[5xbj]] – CjFlgK <br />
 +
**[[2d4y]] – StFlgK <br />
 +
**[[4ut1]] – FlgK – ''Burkholderia pseudomallei''<br />
 +
 +
*Flagellar protein FlgL or flagellar hook-associated protein 3
 +
 +
**[[5yti]] – LpFlgL – ''Legionella pneumophila''<br />
 +
**[[5ziz]], [[5zj0]] – XcFlgL (mutant) <br />
 +
**[[5ziy]] – BcFlgL – ''Bacillus cereus''<br />
 +
**[[2d4x]] – StFlgL <br />
-
*Flagellar protein FlgL
+
*Flagellar protein FlhA
-
**[[6yti]] – LpFlgL – ''Legionella pneumophila''<br />
+
**[[6ch1]], [[6ai0]], [[3a5i]] – StFlhA cytoplasmic domain<br />
 +
**[[6ai3]], [[6ai2]], [[6ai1]] – StFlhA cytoplasmic domain (mutant)<br />
 +
**[[3myd]] – HpFlhA cytoplasmic domain<br />
 +
**[[3mix]] – BsFlhA cytoplasmic domain – ''Bacillus subtilis''<br />
 +
**[[6ch2]] – StFlhA cytoplasmic domain + FliD + FliT<br />
*Flagellar protein FlhB
*Flagellar protein FlhB
Line 72: Line 113:
**[[3b1s]] – AaFlhB C-terminal – ''Aquifex aeolicus''<br />
**[[3b1s]] – AaFlhB C-terminal – ''Aquifex aeolicus''<br />
**[[3b0z]] – StFlhB C-terminal <br />
**[[3b0z]] – StFlhB C-terminal <br />
 +
 +
*Flagellar protein FlhE
 +
 +
**[[4qxl]] – SeFlhE<br />
*Flagellar protein FlhF
*Flagellar protein FlhF
Line 78: Line 123:
**[[2px3]] – BsFlhF + GDP<br />
**[[2px3]] – BsFlhF + GDP<br />
**[[2px0]] – BsFlhF + GMPPNP<br />
**[[2px0]] – BsFlhF + GMPPNP<br />
 +
 +
*Flagellar protein FliD or flagellar hook-associated protein 2
 +
 +
**[[5xlk]], [[5xlj]] – FliD D2-D3 domain - Serratia marcescens<br />
 +
**[[5h5w]], [[5h5v]] – EcFliD D2-D3 domain – Escherichia coli<br />
 +
**[[5h5t]] – StFliD D2-D3 domain <br />
 +
**[[5hfy]] – PaFliD residues 78-405 <br />
 +
 +
*Flagellar protein FliF or flagellar M-ring protein
 +
 +
**[[5tdy]] – TmFliF C-terminal + FliG <br />
 +
 +
*Flagellar protein FliG or flagellar motor switch protein
 +
 +
**[[3usy]], [[3usw]] – HpFliG <br />
 +
**[[5wuj]] – HpFliG N-terminal + FliF <br />
 +
**[[3hjl]] – AaFliG <br />
 +
**[[3ajc]] – TmFliG (mutant) <br />
 +
**[[1qc7]] – TmFliG C-terminal <br />
 +
**[[1lkv]] – TmFliG residues 104-335 <br />
 +
 +
*Flagellar protein FliH
 +
 +
**[[5b0o]] – StFliS + FliI <br />
 +
 +
*Flagellar protein FliI or flagellum-specific ATP synthase
 +
 +
**[[2dpy]] – StFliI <br />
 +
 +
*Flagellar protein FliJ
 +
 +
**[[3ajw]] – StFliJ <br />
 +
 +
*Flagellar protein FliL
 +
 +
**[[6ahq]], [[6ahp]] – FliL fragment – Vibrio alginolyticus <br />
 +
 +
*Flagellar protein FliM
 +
 +
**[[4gc8]] – HpFliM middle domain <br />
 +
**[[5x0z]] – HpFliM + SPEE <br />
 +
**[[4fq0]] – HpFliM + FliG <br />
 +
**[[2hp7]] – TmFliM Chec-like domain <br />
 +
**[[4qrm]], [[4fhr]], [[3soh]] – TmFliM + FliG <br />
 +
**[[1f4v]] – EcFliM C-terminal + CheY <br />
 +
 +
*Flagellar protein FliN
 +
 +
**[[1yab]] – TmFliN <br />
 +
**[[5xrw]] – HpFliN + FliY <br />
 +
 +
*Flagellar protein FliP
 +
 +
**[[5h72]] – TmFliP periplasmic domain <br />
 +
 +
*Flagellar proteins FliP+FliQ+FliR
 +
 +
**[[6r69]], [[6f2d]] – SeFliP + SeFliQ + SeFliR – Cryo EM <br />
*Flagellar protein FliS
*Flagellar protein FliS
-
**[[5maw]] – BsFliS + flagellin<br />
+
**[[5xef]] – BcFliS <br />
 +
**[[1vh6]] – BsFliS <br />
 +
**[[1orj]] – AaFliS <br />
 +
**[[3iqc]] – HpFliS <br />
 +
**[[5maw]], [[6gow]] – BsFliS + flagellin<br />
**[[1ory]] – AaFliS + flagellin<br />
**[[1ory]] – AaFliS + flagellin<br />
 +
**[[3k1i]] – HpFliS + protein <br />
 +
 +
*Flagellar protein FliT
 +
 +
**[[3a7m]] – StFliT <br />
 +
**[[5ks6]] – StFliT - NMR <br />
 +
**[[5gna]] – StFliT + FliD <br />
 +
**[[3nkz]] – FliT – Yersinia enterocolitica <br />
 +
**[[3h3m]] – FliT – Bordetella bronchiseptica<br />
 +
 +
*Flagellar protein FliY
 +
 +
**[[4hyn]] – TmFliY Chec-like domain <br />
 +
**[[5xrw]] – HpFliY + FliN <br />
 +
}}
}}
====Lists of Flagellar Structures====
====Lists of Flagellar Structures====

Revision as of 08:30, 2 July 2019

PDB ID 1io1

Drag the structure with the mouse to rotate

Contents

3D structures of flagellar protein

Updated on 02-July-2019

Lists of Flagellar Structures

These are automatically-generated lists of PDB codes.


and there are undoubtedly other flagellum-related Categories ...

See Also

Within Proteopedia:

External Links

</StructureSection>

References and Notes

  1. ↑ Lockman HA, Curtiss R 3rd. Salmonella typhimurium mutants lacking flagella or motility remain virulent in BALB/c mice. Infect Immun. 1990 Jan;58(1):137-43. PMID:2152887
  2. ↑ Daniels R, Vanderleyden J, Michiels J. Quorum sensing and swarming migration in bacteria. FEMS Microbiol Rev. 2004 Jun;28(3):261-89. PMID:15449604
  3. ↑ Yildiz FH, Visick KL. Vibrio biofilms: so much the same yet so different. Trends Microbiol. 2009 Mar;17(3):109-18. Epub 2009 Feb 21. PMID:19231189 doi:10.1016/j.tim.2008.12.004
  4. ↑ Lemon KP, Higgins DE, Kolter R. Flagellar motility is critical for Listeria monocytogenes biofilm formation. J Bacteriol. 2007 Jun;189(12):4418-24. Epub 2007 Apr 6. PMID:17416647 doi:10.1128/JB.01967-06
  5. ↑ Guerry P. Campylobacter flagella: not just for motility. Trends Microbiol. 2007 Oct;15(10):456-61. Epub 2007 Oct 24. PMID:17920274 doi:10.1016/j.tim.2007.09.006
  6. ↑ Minamino T, Imada K, Namba K. Mechanisms of type III protein export for bacterial flagellar assembly. Mol Biosyst. 2008 Nov;4(11):1105-15. Epub 2008 Sep 24. PMID:18931786 doi:10.1039/b808065h

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Eric Martz, Joel L. Sussman, Fadel A. Samatey, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Flagellar_protein"
Personal tools