Chaperonin

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== 3D Structures of Chaperonin ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*'''Group I'''
 
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*''Large subunit''
 
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**[[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR />
 
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**[[1sjp]], [[3rtk]] – MtGroEL2 residues 42-539<BR />
 
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**[[2eu1]], [[4v43]], [[1oel]], [[1grl]], [[2yey]], [[4wsc]], [[4wgl]], [[5opw]] – EcGroEL (mutant) - ''Escherichia coli''<BR />
 
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**[[3e76]], [[2nwc]], [[1xck]], [[1ss8]], [[4hel]] – EcGroEL<BR />
 
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**[[3c9v]], [[3cau]], [[2ynj]], [[5w0s]] – EcGroEL – Cryo EM<BR />
 
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**[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR />
 
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**[[1dk7]], [[1la1]] - EcGroEL apical domain<br />
 
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**[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR />
 
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**[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR />
 
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**[[3osx]] - CPN60 apical domain – ''Xenorhabdus nematophila''<br />
 
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**[[1iok]] – CPN60 – ''Paracoccus denitrificans''<br />
 
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**[[5da8]] - GroEL – ''Chlorobium tepidum''<br />
 
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**[[5cdk]], [[5cdj]], [[5cdi]] - GroEL apical domain – ''Chlamydomonas reinhardtii''<br />
 
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*''Large subunit binary complex''
 
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**[[1kp8]] - EcGroEL (mutant) + ATP<BR />
 
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**[[4aar]], [[4aas]], [[4aau]], [[4ab2]], [[4ab3]] - EcGroEL (mutant) + ATP – Cryo EM<br />
 
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**[[1sx3]] - EcGroEL + ATP<BR />
 
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**[[1sx4]] - EcGroEL + ADP<BR />
 
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**[[4ki8]] - EcGroEL (mutant) + ADP<br />
 
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**[[1mnf]] – EcGroEL + polypeptide<BR />
 
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**[[2cgt]] – EcGroEL + capsid assbly protein GP31 – EM<BR />
 
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**[[1dkd]] - EcGroEL apical domain + polypeptide<br />
 
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**[[4pj1]] - GroEL + ADP – human<br />
 
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*''Small subunit''
 
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**[[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR />
 
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**[[1wnr]] – TtCPN10 residues 1-94<BR />
 
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**[[1p3h]], [[1hx5]] – MtCPN10<BR />
 
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**[[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR />
 
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**[[1egs]] - GroES residues 19-27 - NMR
 
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*''Large + small subunit''
 
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**[[1svt]], [[1pcq]] - EcGroEL + GroES<BR />
 
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**[[1pf9]], [[1aon]], [[4pko]], [[5opx]] - EcGroEL + GroES + ADP<BR />
 
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**[[3wvl]] - EcGroEL (mutant) + GroES + ATP<br />
 
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**[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR />
 
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**[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR />
 
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**[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br />
 
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**[[4v4o]], [[4pkn]] - TtCPN60 + CPN10 + ADP
 
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*'''Group II'''
 
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**[[3izh]], [[3izi]], [[3izj]], [[3izk]], [[3izl]], [[3izm]], [[3izn]], [[3los]], [[3iyf]], [[3j3x]] – MmCPN – ''Methanococcus maripaludis'' – EM<BR />
 
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**[[3kfb]], [[3kfe]], [[3kfk]] – MmCPN<BR />
 
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**[[5w79]] - MmCPN (mutant)<br />
 
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**[[3j02]], [[3j03]] – MmCPN (mutant) – Cryo EM<br />
 
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**[[3ruq]] - MmCPN + ADP<br />
 
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**[[3rus]], [[5w74]] - MmCPN (mutant) + ADP<br />
 
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**[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
 
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**[[3ruv]] - MmCPN (mutant) + ATP analog<br />
 
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*'''CCT'''
 
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**[[2xsm]], [[4b2t]] – bCPN CCT – bovine<BR />
 
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**[[4v81]], [[4v94]], [[4v8r]] – CPN CCT - yeast<br />
 
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**[[3iyg]], [[4a0o]] - bCPN CCT – Cryo EM<BR />
 
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**[[4a0v]] - bCPN CCT + AMPPNP – Cryo EM<br />
 
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**[[4a0w]] - bCPN CCT + ADP + AlF3 – Cryo EM<br />
 
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**[[4a13]] - bCPN CCT + ADP – Cryo EM<br />
 
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**[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
 
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**[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
 
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*'''Hsp33'''
 
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See [[Heat Shock Proteins]]
 
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*'''Thermosome'''
 
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**[[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR />
 
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**[[1a6e]] - TaTherm α+β subunits + ADP<BR />
 
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**[[1ass]], [[1asx]] - TaTherm α apical domain<BR />
 
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**[[1e0r]] – TaTherm β apical domain<br />
 
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**[[3ko1]] – AtTherm α subunit– ''Acidianus tengchongensis''<br />
 
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**[[3j1b]], [[3j1c]], [[3j1e]] - AtTherm α subunit – Cryo EM <br />
 
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**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
 
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**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
 
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**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – ''Thermococcus KS-1''<br />
 
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**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
 
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**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
 
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**[[4xcd]] - SsTherm β subunit + ADP – ''Sulfolobus solfataricus''<br />
 
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**[[4xcg]], [[4xci]] - SsTherm α+β subunits + ADP<br />
 
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**[[1lep]] – CPN-10 – ''Mycobacterium leprae''
 
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*'''Group III'''
 
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*''Thermosome''
 
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**[[5x9u]] - ChTherm α subunit + ADP – ''Carboxydothermus hydrogenoformans''<br />
 
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**[[5x9v]] - ChTherm α subunit + ANP <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:23, 6 May 2019

E. coli GroEL (green)/GroES (magenta) complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry 1pcq)

Drag the structure with the mouse to rotate

References

  1. ↑ Apetri AC, Horwich AL. Chaperonin chamber accelerates protein folding through passive action of preventing aggregation. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17351-5. doi:, 10.1073/pnas.0809794105. Epub 2008 Nov 5. PMID:18987317 doi:http://dx.doi.org/10.1073/pnas.0809794105
  2. ↑ Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S. Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. Cell. 1998 Apr 3;93(1):125-38. PMID:9546398
  3. ↑ Leitner A, Joachimiak LA, Bracher A, Monkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J. The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure. 2012 May 9;20(5):814-25. Epub 2012 Apr 12. PMID:22503819 doi:10.1016/j.str.2012.03.007
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