4bwm

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<StructureSection load='4bwm' size='340' side='right'caption='[[4bwm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='4bwm' size='340' side='right'caption='[[4bwm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bwm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BWM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bwm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwm OCA], [https://pdbe.org/4bwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwm RCSB], [https://www.ebi.ac.uk/pdbsum/4bwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwm ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bwj|4bwj]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwm OCA], [http://pdbe.org/4bwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bwm RCSB], [http://www.ebi.ac.uk/pdbsum/4bwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwm ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/DPO1_THEAQ DPO1_THEAQ]]
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Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics.
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Structure and Function of an RNA-Reading Thermostable DNA Polymerase.,Blatter N, Bergen K, Nolte O, Welte W, Diederichs K, Mayer J, Wieland M, Marx A Angew Chem Int Ed Engl. 2013 Sep 17. doi: 10.1002/anie.201306655. PMID:24106012<ref>PMID:24106012</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bwm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase|DNA polymerase]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 25104]]
 
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[[Category: DNA-directed DNA polymerase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bergen, K]]
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[[Category: Synthetic construct]]
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[[Category: Blatter, N]]
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[[Category: Thermus aquaticus]]
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[[Category: Diederichs, K]]
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[[Category: Bergen K]]
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[[Category: Marx, A]]
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[[Category: Blatter N]]
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[[Category: Welte, W]]
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[[Category: Diederichs K]]
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[[Category: Transferase-dna-rna complex]]
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[[Category: Marx A]]
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[[Category: Welte W]]

Revision as of 17:13, 7 September 2022

KlenTaq mutant in complex with a RNA/DNA hybrid

PDB ID 4bwm

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