This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Methyl CpG binding protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 18: Line 18:
== Structural highlights ==
== Structural highlights ==
<scene name='59/597003/Cv/3'>Thymine from the mismatched G:T pair flips out from the DNA strand and interchelates with MBD4 residues Lys and Leu</scene><ref>PMID:22740654</ref>.
<scene name='59/597003/Cv/3'>Thymine from the mismatched G:T pair flips out from the DNA strand and interchelates with MBD4 residues Lys and Leu</scene><ref>PMID:22740654</ref>.
 +
 +
==3D structures of methyl CpG binding protein==
 +
[[Methyl CpG binding protein 3D structures]]
 +
</StructureSection>
</StructureSection>
Line 36: Line 40:
**[[2l2l]] - hMBD2 coiled-coil domain + transcriptional repressor p66-α coiled-coil domain – NMR<br />
**[[2l2l]] - hMBD2 coiled-coil domain + transcriptional repressor p66-α coiled-coil domain – NMR<br />
 +
**[[6ogj]], [[6ogk]] – hMBD2 MBD + DNA <br />
**[[5bt2]] – hMBD2 MBD + methylated DNA <br />
**[[5bt2]] – hMBD2 MBD + methylated DNA <br />
-
**[[2ky8]] – cMBD2 MBD domain + DNA containing cytidine and uridine derivatives - NMR - chicken<br />
 
**[[1qk9]] - hMCP2 MBD domain – NMR<br />
**[[1qk9]] - hMCP2 MBD domain – NMR<br />
**[[3c2i]] – hMCP2 MBD domain (mutant) + DNA<br />
**[[3c2i]] – hMCP2 MBD domain (mutant) + DNA<br />
**[[6cnp]], [[6cnq]], [[6c2f]], [[6c1y]], [[6c1v]], [[6c1u]], [[6c1t]], [[6c1a]] – hMCP2 residues 143-220 + DNA<br />
**[[6cnp]], [[6cnq]], [[6c2f]], [[6c1y]], [[6c1v]], [[6c1u]], [[6c1t]], [[6c1a]] – hMCP2 residues 143-220 + DNA<br />
 +
**[[2ky8]] – cMBD2 MBD domain + DNA containing cytidine and uridine derivatives - NMR - chicken<br />
**[[1ub1]] – cMCP2 MBD domain – NMR<br />
**[[1ub1]] – cMCP2 MBD domain – NMR<br />
Line 50: Line 55:
*Methyl CpG binding protein 4 (MBD4)
*Methyl CpG binding protein 4 (MBD4)
-
**[[1ngn]] - MBD4 glycosylate domain – mouse<br />
 
**[[3iho]], [[4e9e]] – hMBD4 glycosylate domain<br />
**[[3iho]], [[4e9e]] – hMBD4 glycosylate domain<br />
**[[4e9g]] – hMBD4 glycosylate domain + DNA <br />
**[[4e9g]] – hMBD4 glycosylate domain + DNA <br />
**[[4dk9]], [[4e9f]] – hMBD4 glycosylate domain + DNA containing abasic dideoxyribose<br />
**[[4dk9]], [[4e9f]] – hMBD4 glycosylate domain + DNA containing abasic dideoxyribose<br />
-
**[[4ew4]] – mMBD4 glycosylate domain + DNA containing abasic dideoxyribose<br />
 
-
**[[4evv]] – mMBD4 glycosylate domain + DNA containing mismatch<br />
 
-
**[[4ew0]] – mMBD4 glycosylate domain (mutant) + DNA containing hydroxymethyluracil<br />
 
**[[4e9h]], [[4ea4]], [[4ea5]] – hMBD4 glycosylate domain (mutant) + DNA containing hydroxymethyluracil<br />
**[[4e9h]], [[4ea4]], [[4ea5]] – hMBD4 glycosylate domain (mutant) + DNA containing hydroxymethyluracil<br />
-
**[[3vxv]], [[3vxx]], [[3vyb]], [[3vyq]] – mMBD4 MBD + DNA containing cytidine derivative<br />
 
**[[4lg7]], [[2moe]] – hMBD4 MBD + DNA containing cytidine derivative<br />
**[[4lg7]], [[2moe]] – hMBD4 MBD + DNA containing cytidine derivative<br />
**[[5chz]] – hMBD4 MBD + DNA containing mismatch<br />
**[[5chz]] – hMBD4 MBD + DNA containing mismatch<br />
**[[4ofa]], [[4ofe]], [[4ofh]] – hMBD4 MBD (mutant) + DNA containing mismatch<br />
**[[4ofa]], [[4ofe]], [[4ofh]] – hMBD4 MBD (mutant) + DNA containing mismatch<br />
 +
**[[1ngn]] - mMBD4 glycosylate domain – mouse<br />
 +
**[[4ew4]] – mMBD4 glycosylate domain + DNA containing abasic dideoxyribose<br />
 +
**[[4evv]] – mMBD4 glycosylate domain + DNA containing mismatch<br />
 +
**[[4ew0]] – mMBD4 glycosylate domain (mutant) + DNA containing hydroxymethyluracil<br />
 +
**[[3vxv]], [[3vxx]], [[3vyb]], [[3vyq]] – mMBD4 MBD + DNA containing cytidine derivative<br />
 +
 +
Methyl CpG binding protein 11 (MBD11)
 +
**[[6acv]] – MBD11 MBD domain – ''Arabidopsis thaliana'' - NMR<br />
}}
}}

Revision as of 09:44, 30 October 2019

Structure of mouse MBD4 glycosylate domain complex with DNA containing mismatch, ethylene glycol and Ni+2 ion (green) (PDB code 4evv).

Drag the structure with the mouse to rotate

3D structures of methyl CpG binding protein

Updated on 30-October-2019

Methyl CpG binding protein 11 (MBD11)

References

  1. ↑ Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:http://dx.doi.org/10.1002/bies.10008
  2. ↑ Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
  3. ↑ Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res. 2012 Jun 27. PMID:22740654 doi:10.1093/nar/gks628

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Methyl_CpG_binding_protein"
Personal tools