Proteasome

== 3D Structures of Proteasome ==

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* Proteasome 20S core

**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />

**[[6rgq]], [[6r70]] – h20S core – Cryo EM<br />

**[[1iru]] – 20S core - bovine<br />

**[[3une]] – m20S core – mouse<br />

**[[3unh]] – m20S core (immuno)<br />

**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />

**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[6hwc]] - y20S core (mutant)<br />

**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />

**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />

**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />

**[[1q5q]] - Re20S core<br />

**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br />

**[[6he7]] – Af20S - Cryo EM<br />

**[[6qm8]] – Lt20S core – ''Leishmania tarentolae'' - Cryo EM<br />

**[[6muw]] – Pf20S – ''Plasmodium falciparum'' - Cryo EM<br />

**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />

**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />

*Proteasome 20S+activator protein

**[[6rey]] – h20S + activator PA200 – Cryo EM<br />

**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />

**[[1z7q]], [[1fnt]] – y20S core+PA26<br />

**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />

**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />

**[[6bgo]], [[6bgl]] – Mt20S + activator<br />

**[[6mux]], [[6muv]] – Pf20S + activator PA28 - Cryo EM<br />

**[[6hed]], [[6hec]], [[6hea]], [[6he9]], [[6he8]], [[6he5]] – Af20S + PAN – Cryo EM<br />

*Proteasome 20S+inhibitor

**[[4r67]] – h20S + cancer drug<br />

**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]], [[6avo]], [[6e5b]] - h20S + inhibitor<br />

**[[5a0q]] - h20S + substrate analog<br />

**[[3unb]], [[3unf]] – m20S + inhibitor<br />

**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]], [[6hwb]], [[6hwa]], [[6hw9]], [[6hw8]], [[6hw7]], [[6hw6]], [[6hw5]], [[6hw4]], [[6hw3]], [[6hw0]], [[6hvy]], [[6hvx]], [[6hvw]], [[6hvv]], [[6hvu]], [[6hvt]], [[6hvs]], [[6hvr]], [[6hva]], [[6hv7]], [[6hv5]], [[6hv4]], [[6hv3]], [[6huv]], [[6huu]], [[6huq]], [[6huc]], [[6hub]], [[6htr]], [[6htp]], [[6htd]], [[6htc]], [[6htb]], [[6h39]] – y20S core+inhibitor<br />

**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]], [[6hwf]], [[6g8n]], [[6g8m]], [[6g7f]] – y20S (mutant) + inhibitor<br />

**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />

**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />

**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />

**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br />

**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />

**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />

**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]], [[6hwe]], [[6hwd]] - y20S (mutant) + cancer drug<br />

**[[4x6z]] - y20S + modulator<br />

**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />

**[[5l5a]] - y20S + h20S beta5i<br />

**[[5ltt]] - y20S + h20S beta5i + inhibitor<br />

**[[5l5b]], [[5l5r]] - y20S + h20S beta5i + h20S beta6<br />

**[[5l5w]] - y20S + h20S beta5c + h20S beta6<br />

**[[5l5x]], [[5l60]], [[5l61]] - y20S + h20S beta5c + h20S beta6 + inhibitor<br />

**[[5l5y]], [[5l5z]] - y20S + h20S beta5c + h20S beta6 + cancer drug<br />

**[[5l5d]], [[5l5h]], [[5l5q]], [[5l5i]], [[5l5j]], [[5l5o]], [[5l5p]], [[5l5s]], [[5l5t]], [[5l5u]], [[5l5v]], [[5l62]], [[5l63]], [[5l64]], [[5l68]], [[5l69]], [[5l6a]], [[5l6c]], [[5m2b]] - y20S + h20S beta5i + h20S beta6 + inhibitor<br />

**[[5l5e]], [[5l5f]] - y20S + h20S beta5i + h20S beta6 + cancer drug<br />

**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />

**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />

**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />

**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />

**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]], [[6ode]], [[6ocz]], [[6ocw]] – Mt20S core+inhibitor<br />

**[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br />

* Proteasome partial 20S particle

**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain<br />

**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />

**[[3fp9]] – MtATPase chains A-L<br />

**[[1j2p]] – AfPRTS α subunit<br />

**[[2jay]] – MtPRTS β subunit<br />

**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />

*Proteasome partial 26S particle

**[[5l4k]] - hPRTS lid - CryoEM<br />

**[[5dsv]] - hPRTS subunit a type-3<br />

**[[1p9c]] – hPRTS subunit 4 C-terminal<br />

**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />

**[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br />

**[[1yx4]] - hPRTS subunit 4 – NMR<br />

**[[1yx5]], [[1yx6]], [[2kde]], [[2kdf]], [[6mun]] - hPRTS subunit 4+ubiquitin – NMR<br />

**[[2o95]], [[2o96]] - hPRTS subunit 7<br />

**[[3kw6]] - hPRTS subunit 8<br />

**[[2krk]] - hPRTS subunit 8 – NMR<br />

**[[1qym]], [[1uoh]] - hPRTS subunit 10<br />

**[[1tr4]] - hPRTS subunit 10 – NMR<br />

**[[4nik]] - hPRTS subunit 10 + single-chain Fv<br />

**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br />

**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />

**[[3aji]] - mPRTS subunit 10 + subunit 4<br />

**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />

**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />

**[[4ady]] - yPRTS subunit RPN2<br />

**[[5zmr]] - yPRTS subunit RPN5 N terminal – NMR<br />

**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br />

**[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br />

**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br />

**[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br />

**[[2mr3]] - yPRTS subunit RPN9 – NMR<br />

**[[2mqw]] - yPRTS subunit RPN9 N terminal – NMR<br />

**[[2mri]] - yPRTS subunit RPN9 C terminal – NMR<br />

**[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br />

**[[4b0z]] - yPRTS subunit RPN12<br />

**[[2z4d]] - yPRTS subunit RPN13<br />

**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br />

**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /

**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br />

**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />

*Proteasome 26S particle

**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] - hPRTS - Cryo EM<br />

**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />

**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – PRTS – rat - Cryo EM<br />

**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]] – yPRTS – Cryo EM<br />

**[[5wvk]] - yPRTS + ADP - Cryo EM<br />

**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - yPRTS + ATP - Cryo EM<br />

**[[5mpb]] - yPRTS + AMPPNP - Cryo EM<br />

**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />

**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />

**[[6ef3]], [[6ef2]], [[6ef1]], [[6ef0]] – yPRTS + ubiquitin-L40 – Cryo EM<br />

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