Johnson's Monday Lab Sandbox for Insulin Receptor
From Proteopedia
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===How Insulin Binds=== | ===How Insulin Binds=== | ||
| - | The insulin receptor unit has four separate sites for the insulin molecule to bind to. There are two pairs of two identical binding sites referred to as 1 and 1' and then 2 and 2'. The insulin molecules bind to these sites mostly through [http://en.wikipedia.org/wiki/Hydrophobic_effect hydrophobic interactions]. Despite a majority of the interactions being similar, sites 1 and 1' have a higher binding affinity than sites 2 and 2' due to site one having a larger surface area (706 square angstroms) exposed for insulin to bind to compared to site 2 (394 square angstroms)<ref | + | The insulin receptor unit has four separate sites for the insulin molecule to bind to. There are two pairs of two identical binding sites referred to as 1 and 1' and then 2 and 2'. The insulin molecules bind to these sites mostly through [http://en.wikipedia.org/wiki/Hydrophobic_effect hydrophobic interactions]. Despite a majority of the interactions being similar, sites 1 and 1' have a higher binding affinity than sites 2 and 2' due to site one having a larger surface area (706 square angstroms) exposed for insulin to bind to compared to site 2 (394 square angstroms)<ref name="Uchikawa" />. |
| - | It was found that at least three insulin molecules would have to bound to the receptor for the receptor to take on its active “T-state” conformation <ref | + | It was found that at least three insulin molecules would have to bound to the receptor for the receptor to take on its active “T-state” conformation <ref name="Uchikawa" />. The difference between have the fully bound state with four insulins and the three insulin bound state is minimal compared to the difference between two and three insulins bound <ref name="Uchikawa" />. |
Revision as of 23:04, 21 March 2020
Your Heading Here (maybe something like 'Structure')
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