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User:Daniel Mulawa/Sandbox 1
From Proteopedia
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<ref name="Khan">PMID:30150752</ref> | <ref name="Khan">PMID:30150752</ref> | ||
== Relevance == | == Relevance == | ||
| + | APP build up leads to Amyloid plaques in brain | ||
| + | Inhibition of γ-secretase could be potential AD treatment | ||
| + | Location of majority of mutations | ||
| + | Over 200 mutations that cause AD | ||
| + | AD mutations heavily target interface between PS1 and APP | ||
| + | Important to look at differences between substrates | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 19:42, 24 March 2020
=Human Gamma Secretase=
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ 3.0 3.1 Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, Berger I, Schaffitzel C, Fraser PE, Martins RN, Verdile G. Efficient production of a mature and functional gamma secretase protease. Sci Rep. 2018 Aug 27;8(1):12834. doi: 10.1038/s41598-018-30788-w. PMID:30150752 doi:http://dx.doi.org/10.1038/s41598-018-30788-w
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