Gamma Secretase

Introduction

Figure 1

5A63 Article

Background

Gamma Secretase is a transmembrane aspartate protease Catalyzes peptide bond hydrolysis of type I integral membrane proteins Such as Notch, APP, and various other substrates 3 residue segments; allow binding and cleavage Generates amyloid-β (Aβ) Important for neural processes Implications with Alzheimer’s disease (AD) Drug target GS inhibitors Dangerous side effects

practice

Structural highlights

Relevance and Disease

APP build up leads to Amyloid plaques in brain Inhibition of γ-secretase could be potential AD treatment Location of majority of mutations Over 200 mutations that cause AD AD mutations heavily target interface between PS1 and APP Important to look at differences between substrates

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.