User:Milena Ortiz Ribeiro/Sandbox 1
From Proteopedia
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==Struture== | ==Struture== | ||
| + | The mitochondrial transcription factor A is a 25 kDa protein belonging to the high protein group mobility, which are characterized by binding to DNA through registered HMG-box domains and important in the organization and chromatin function. TFAM features two HMG-box domains in the form of "L" composed of three α-helices, separated by a linker of 27 amino acid residues and a loaded C-terminal tail, of 25 waste. The TFM HMG-box domains that present tandem repetitions and are stabilized by hydrophobic nuclei. <ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref> | ||
== Function == | == Function == | ||
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the maintenance of mtDNA copy number.The in vivo packaging of mtDNA by TFAMhas been estimated at 35–50 to 1,000–1,700 molecules per genome. Higher TFAM:mtDNA ratios are interpreted as resulting in tightercompaction of mtDNA and reduced accessibility to transcrip-tion, replication, or repair factors, whereas lower ratios are pre-dicted to permit increased accessibility.<ref>PMID:26437364 </ref> | the maintenance of mtDNA copy number.The in vivo packaging of mtDNA by TFAMhas been estimated at 35–50 to 1,000–1,700 molecules per genome. Higher TFAM:mtDNA ratios are interpreted as resulting in tightercompaction of mtDNA and reduced accessibility to transcrip-tion, replication, or repair factors, whereas lower ratios are pre-dicted to permit increased accessibility.<ref>PMID:26437364 </ref> | ||
| - | <ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref> | ||
<ref>PMID: 32371956 </ref> | <ref>PMID: 32371956 </ref> | ||
<ref>PMID: 31419493 </ref> | <ref>PMID: 31419493 </ref> | ||
Revision as of 14:47, 16 June 2020
Your Heading Here (maybe something like 'Structure')
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References
- ↑ TONOLLI, P.N. O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas. São Paulo. 2013.
- ↑ Picca A, Lezza AM. Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. Mitochondrion. 2015 Nov;25:67-75. doi: 10.1016/j.mito.2015.10.001. Epub 2015 Oct , 3. PMID:26437364 doi:http://dx.doi.org/10.1016/j.mito.2015.10.001
- ↑ Liu Y, Jin M, Wang Y, Zhu J, Tan R, Zhao J, Ji X, Jin C, Jia Y, Ren T, Xing J. MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. Signal Transduct Target Ther. 2020 May 5;5(1):59. doi: 10.1038/s41392-020-0155-5. PMID:32371956 doi:http://dx.doi.org/10.1038/s41392-020-0155-5
- ↑ Kozhukhar N, Alexeyev MF. Limited predictive value of TFAM in mitochondrial biogenesis. Mitochondrion. 2019 Nov;49:156-165. doi: 10.1016/j.mito.2019.08.001. Epub 2019, Aug 13. PMID:31419493 doi:http://dx.doi.org/10.1016/j.mito.2019.08.001
- ↑ Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, Bogenhagen DF, Temiakov D, Suzuki CK. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Mol Cell. 2013 Jan 10;49(1):121-32. doi: 10.1016/j.molcel.2012.10.023. Epub 2012 , Nov 29. PMID:23201127 doi:http://dx.doi.org/10.1016/j.molcel.2012.10.023
- ↑ Araujo LF, Siena ADD, Placa JR, Brotto DB, Barros II, Muys BR, Biagi CAO Jr, Peronni KC, Sousa JF, Molfetta GA, West LC, West AP, Leopoldino AM, Espreafico EM, Silva WA Jr. Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. Sci Rep. 2018 Sep 21;8(1):14190. doi: 10.1038/s41598-018-31170-6. PMID:30242167 doi:http://dx.doi.org/10.1038/s41598-018-31170-6
- ↑ Stiles AR, Simon MT, Stover A, Eftekharian S, Khanlou N, Wang HL, Magaki S, Lee H, Partynski K, Dorrani N, Chang R, Martinez-Agosto JA, Abdenur JE. Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. Mol Genet Metab. 2016 Sep;119(1-2):91-9. doi: 10.1016/j.ymgme.2016.07.001. Epub, 2016 Jul 4. PMID:27448789 doi:http://dx.doi.org/10.1016/j.ymgme.2016.07.001
