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2vr3

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<StructureSection load='2vr3' size='340' side='right'caption='[[2vr3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='2vr3' size='340' side='right'caption='[[2vr3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vr3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VR3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vr3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fzb|1fzb]], [[1rf1|1rf1]], [[1lt9|1lt9]], [[1fid|1fid]], [[1fzc|1fzc]], [[1n8e|1n8e]], [[1re4|1re4]], [[1n86|1n86]], [[1fza|1fza]], [[1dug|1dug]], [[1re3|1re3]], [[1ltj|1ltj]], [[1fzg|1fzg]], [[1fzf|1fzf]], [[2fib|2fib]], [[2ffd|2ffd]], [[1fze|1fze]], [[1rf0|1rf0]], [[1fic|1fic]], [[1fib|1fib]], [[3fib|3fib]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fzb|1fzb]], [[1rf1|1rf1]], [[1lt9|1lt9]], [[1fid|1fid]], [[1fzc|1fzc]], [[1n8e|1n8e]], [[1re4|1re4]], [[1n86|1n86]], [[1fza|1fza]], [[1dug|1dug]], [[1re3|1re3]], [[1ltj|1ltj]], [[1fzg|1fzg]], [[1fzf|1fzf]], [[2fib|2fib]], [[2ffd|2ffd]], [[1fze|1fze]], [[1rf0|1rf0]], [[1fic|1fic]], [[1fib|1fib]], [[3fib|3fib]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr3 OCA], [http://pdbe.org/2vr3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr3 OCA], [https://pdbe.org/2vr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:[http://omim.org/entry/202400 202400]]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
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[[https://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:[https://omim.org/entry/202400 202400]]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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[[https://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 11:44, 30 March 2022

Structural and Biochemical Characterization of Fibrinogen binding to ClfA from Staphylocccus aureus

PDB ID 2vr3

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