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6xxw
From Proteopedia
(Difference between revisions)
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==Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.== | ==Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.== | ||
| - | <StructureSection load='6xxw' size='340' side='right'caption='[[6xxw]]' scene=''> | + | <StructureSection load='6xxw' size='340' side='right'caption='[[6xxw]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dict6 Dict6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxw OCA], [http://pdbe.org/6xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxw RCSB], [http://www.ebi.ac.uk/pdbsum/6xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxw ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DICTH_1429 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=309799 DICT6])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxw OCA], [http://pdbe.org/6xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxw RCSB], [http://www.ebi.ac.uk/pdbsum/6xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The beta-d-glucuronidase DtGlcA from Dictyoglomus thermophilum was engineered to generate an active thioglycoligase that is able to catalyse the formation of numerous S-glucuronides. Its X-ray structure analysis indicated the ability of the biocatalyst to bind aromatic thiol acceptors for S-glycosylation. Noteworthily, the DtGlcA mutant was found to be the first thioligase that is able to use a natural sugar donor different from the widely used synthetic para-nitrophenyl glycosides. | ||
| + | |||
| + | Thioglycoligation of aromatic thiols using a natural glucuronide donor.,Kurdziel M, Kopec M, Paris A, Lewinski K, Lafite P, Daniellou R Org Biomol Chem. 2020 Jul 16. doi: 10.1039/d0ob00226g. PMID:32671369<ref>PMID:32671369</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6xxw" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Beta-glucuronidase]] | ||
| + | [[Category: Dict6]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Daniellou R]] | + | [[Category: Daniellou, R]] |
| - | [[Category: Lafite P]] | + | [[Category: Lafite, P]] |
| + | [[Category: Glucuronide]] | ||
| + | [[Category: Glycoside hydrolase]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 06:00, 5 August 2020
Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.
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