Nonstructural protein

From Proteopedia

Revision as of 10:25, 17 February 2021

spinqualitylabelsall models Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle[1]. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NS User:Michael Strong/H1N1/NS1/MSA User:Michael Strong/H1N1/NS2/MSA Student Project 4 for UMass Chemistry 423 Spring 2015. For NS1 of SARS-CoV-2 see SARS-CoV-2 protein NSP1. For NS3 of SARS-CoV-2 see SARS-CoV-2 enzyme Papain-like. For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see SARS-CoV-2 enzyme RdRp. For NS16+NS10 of SARS-CoV-2 see SARS-CoV-2 enzyme 2'-O-MT. Relevance The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See Bailey Dove/Victrelis. Structural highlights [2]. 3D Structures of Nonstructural protein Nonstructural protein 3D structures

References

1. ↑ Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
2. ↑ Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200