Sandbox 1666

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function of Protein

This protein is produced in bacteria, more specifically E. coli. CTX-M Beta-Lactamase is produced in bacteria which causes drug resistance in B-lactam antibiotics, also known as penicillin. It attacks the amide bond in the lactam anitbiotics, which causes deacylation to occur. is the overall structure of CTX-M Beta-Lactamase.

Biological Relevance and Broader Implications

Important Amino Acids

This protein has eight chains. Each chain has eleven separate alpha helices and nine separate beta sheets. Some of the chains bind to GOL to help with stability. Within each chain, there are two of the catalytic amino acid within helix three. The last catalytic amino acid is located in helix seven. Both of these helices form important interactions with the ligands because of those catalytic amino acids, which have been highlighted here.

Structural highlights

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Other Important Features