Sandbox GGC15

Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation^[1]. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA^[2]. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix. They are able to pass another part of the duplex through the cut, and close the cut using ATP^[3].

Function

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.