Sandbox GGC15

(Difference between revisions)

Revision as of 20:29, 27 April 2021

↑ Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L. The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. Epub 2002 Nov 8. PMID:12426403 doi:10.1073/pnas.242259599
↑ ^2.0 ^2.1 ^2.2 Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID:9488644

@@ Line 1: / Line 1: @@
 ==DNA TOPOISOMERASE I==
 <StructureSection load='1A36' size='340' side='right' caption='Caption for this structure' scene=''>
-Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref>DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref>PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix<ref name="Staker et al., 2002">PMID:9488644</ref>. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref name="Staker et al., 2002" />.
+Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref name="Redinbo et al., 1998">DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref name="Staker et al., 2002">PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix<ref name="Staker et al., 2002" />. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref name="Staker et al., 2002" />.
 == Function ==