Immune receptors

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<scene name='70/705725/Cv/3'>Human erythropoietin receptor with erythropoietin</scene> (PDB code [[1cn4]]).
<scene name='70/705725/Cv/3'>Human erythropoietin receptor with erythropoietin</scene> (PDB code [[1cn4]]).
*[[Prolactin receptor]]
*[[Prolactin receptor]]
 +
<scene name='74/749401/Cv/5'>Human prolactin receptor complex with prolactin, Na+ and Cl-</scene> (PDB code [[3mzg]]). The interaction between PRLR and prolactin is strongly pH-dependent and is critically dependent on <scene name='74/749401/Cv/6'>two histidine residues located at PRLP and on prolactin</scene><ref>PMID:20889499</ref>. Water molecules are shown as red spheres. <scene name='74/749401/Cv/7'>Na coordination site is situated between PRLR and prolactin</scene>.
====Type II cytokine receptors====
====Type II cytokine receptors====
=====Interferon receptors=====
=====Interferon receptors=====

Revision as of 14:07, 11 May 2021

Structure of human leukocyte immunoglobulin-like receptor ligand-binding domain (salmon) complex with class I MHC (aqua), β-2 microglobulin (green) and POL polyprotein peptide (pink) (PDB entry 1p7q)

Drag the structure with the mouse to rotate

References

  1. ↑ Thomas R, Matthias T, Witte T. Leukocyte immunoglobulin-like receptors as new players in autoimmunity. Clin Rev Allergy Immunol. 2010 Apr;38(2-3):159-62. doi:, 10.1007/s12016-009-8148-8. PMID:19548123 doi:http://dx.doi.org/10.1007/s12016-009-8148-8
  2. ↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750
  3. ↑ Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Mar 14. PMID:23493555 doi:http://dx.doi.org/10.1073/pnas.1219457110
  4. ↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:http://dx.doi.org/10.1016/j.str.2015.06.019
  5. ↑ Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME. Two independent histidines, one in human prolactin and one in its receptor, are critical for pH dependent receptor recognition and activation. J Biol Chem. 2010 Sep 30. PMID:20889499 doi:10.1074/jbc.M110.172072

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Alexander Berchansky

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