Guanine nucleotide dissociation inhibitor

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== Function ==
== Function ==
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'''Guanine nucleotide dissociation inhibitor''' or Rho GDP (GDI) bind to GDP-bound Rho ('''RhoGDI''') and Rab small GTPase maintaining it in an off-stage and preventing the GTPase localization to the membrane<ref>PMID:8089173</ref>.
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'''Guanine nucleotide dissociation inhibitor''' or '''Rho GDP-dissociation inhibitor''' (GDI) bind to GDP-bound Rho ('''RhoGDI''') and Rab small GTPase maintaining it in an off-stage and preventing the GTPase localization to the membrane<ref>PMID:8089173</ref>.
== Relevance ==
== Relevance ==

Revision as of 08:26, 19 August 2021

Structure of mouse guanine nucleotide dissociation inhibitor (green) complex with GTPase RhoA (grey), geranyl geran, phosphoaminophosphonic acid-guanylate ester and Mg+2 ion (green) (PDB code 4f38).

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3D structures of guanine nucleotide dissociation inhibitor

Updated on 19-August-2021

References

  1. ↑ Peter F, Nuoffer C, Pind SN, Balch WE. Guanine nucleotide dissociation inhibitor is essential for Rab1 function in budding from the endoplasmic reticulum and transport through the Golgi stack. J Cell Biol. 1994 Sep;126(6):1393-406. PMID:8089173
  2. ↑ Jiang WG, Watkins G, Lane J, Cunnick GH, Douglas-Jones A, Mokbel K, Mansel RE. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res. 2003 Dec 15;9(17):6432-40. PMID:14695145

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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